SML1094
CHIR 98014
≥98% (HPLC), powder, GSK-3 inhibitor
别名:
N-6-[2-[[4-(2,4-二氯苯基)-5-(1H-咪唑-1-基）-2-嘧啶基]氨基]乙基] -3-硝基-2,6-吡啶二胺, CHIR-98014
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关于此项目
经验公式（希尔记法）:
C20H17Cl2N9O2
化学文摘社编号:
分子量:
486.31
UNSPSC Code:
12352200
PubChem Substance ID:
NACRES:
NA.77
MDL number:
产品名称
CHIR 98014, ≥98% (HPLC)
SMILES string
NC1=C(C=CC(NCCNC2=NC(C3=C(Cl)C=C(Cl)C=C3)=C(N4C=CN=C4)C=N2)=N1)[N+]([O-])=O
InChI
1S/C20H17Cl2N9O2/c21-12-1-2-13(14(22)9-12)18-16(30-8-7-24-11-30)10-27-20(29-18)26-6-5-25-17-4-3-15(31(32)33)19(23)28-17/h1-4,7-11H,5-6H2,(H3,23,25,28)(H,26,27,29)
InChI key
MDZCSIDIPDZWKL-UHFFFAOYSA-N
assay
≥98% (HPLC)
form
powder
color
white to brown
solubility
DMSO: 0.5 mg/mL, clear (warmed)
storage temp.
−20°C
Quality Level
Application
CHIR 98014已用于小分子型神经元祖细胞(small molecules neural progenitor cell)的生成及其向运动神经元的分化。它也已作为细胞条件培养基中的Wnt/β-连环蛋白激动剂，用于在HT22神经元细胞中进行染色质免疫沉淀(ChIP)分析。
Biochem/physiol Actions
CHIR 98014 是一种糖原合酶激酶 3（GSK-3）抑制剂，对 GSK3α 和 GSK3β 的 IC50 值分别为 0.65 nM 和 0.58 nM。 CHIR98014 对 GSK-3 的选择性是对其他 20 种蛋白激酶（包括最接近的同源物 Cdc2 和 ERK2）的 500 倍至 >10,000 倍。
CHIR 98014 是糖原合酶激酶 3（GSK-3）抑制剂。
Preparation Note
产品在原装密封容器内相当稳定。粉末形式应−20°C储存。
以 0.5 mg/mL 的浓度在 DMSO 中复溶。复溶后，等分并冷冻保存（-20°C）。原液在-20°C条件下可稳定保存6个月。
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Matías A Medina et al.
Translational psychiatry, 8(1), 45-45 (2018-03-06)
Synaptic abnormalities have been described in individuals with autism spectrum disorders (ASD). The cell-adhesion molecule Neuroligin-3 (Nlgn3) has an essential role in the function and maturation of synapses and NLGN3 ASD-associated mutations disrupt hippocampal and cortical function. Here we show
Selective activation of FZD7 promotes mesendodermal differentiation of human pluripotent stem cells.
Diana Gumber et al.
eLife, 9 (2020-12-18)
WNT proteins are secreted symmetry breaking signals that interact with cell surface receptors of the FZD family to regulate a multitude of developmental processes. Studying selectivity between WNTs and FZDs has been hampered by the paucity of purified WNT proteins
Paola Rusmini et al.
Autophagy, 15(4), 631-651 (2018-10-20)
Macroautophagy/autophagy, a defense mechanism against aberrant stresses, in neurons counteracts aggregate-prone misfolded protein toxicity. Autophagy induction might be beneficial in neurodegenerative diseases (NDs). The natural compound trehalose promotes autophagy via TFEB (transcription factor EB), ameliorating disease phenotype in multiple ND
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