跳转至内容
Merck
CN

SML1089

Sigma-Aldrich

AZ191

≥98% (HPLC)

登录查看公司和协议定价

别名:
[2-Methoxy-4-(4-methyl-piperazin-1-yl)-phenyl]-[4-(1-methyl-1H-pyrrolo[2,3-c]pyridin-3-yl)-pyrimidin-2-yl]-amine
经验公式(希尔记法):
C24H27N7O
分子量:
429.52
MDL编号:
UNSPSC代码:
12352200
PubChem化学物质编号:

检测方案

≥98% (HPLC)

形式

powder

颜色

, white to yellow to light brown

溶解性

DMSO: 10 mg/mL, clear

储存温度

−20°C

SMILES字符串

CN1C2=CN=CC=C2C(C3=NC(NC4=C(OC)C=C(N5CCN(C)CC5)C=C4)=NC=C3)=C1

InChI

1S/C24H27N7O/c1-29-10-12-31(13-11-29)17-4-5-21(23(14-17)32-3)28-24-26-9-7-20(27-24)19-16-30(2)22-15-25-8-6-18(19)22/h4-9,14-16H,10-13H2,1-3H3,(H,26,27,28)

InChI key

ZYVXTMKTGDARKR-UHFFFAOYSA-N

生化/生理作用

AZ191 is a cell permeable, potent and selective inhibitor of DYRK1B that promotes a G1 cell cycle arrest.

其他说明

AZ191 has been expertly reviewed and recommended by the Chemical Probes Portal. For more information, please visit the AZ191 probe summary on the Chemical Probes Portal website.

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

法规信息

新产品

分析证书(COA)

输入产品批号来搜索 分析证书(COA) 。批号可以在产品标签上"批“ (Lot或Batch)字后找到。

已有该产品?

在文件库中查找您最近购买产品的文档。

访问文档库

ElShaddai Z White et al.
Scientific reports, 10(1), 12505-12505 (2020-07-29)
Inadequate nutrient intake leads to oxidative stress disrupting homeostasis, activating signaling, and altering metabolism. Oxidative stress serves as a hallmark in developing prostate lesions, and an aggressive cancer phenotype activating mechanisms allowing cancer cells to adapt and survive. It is
Rajeev Singh et al.
Oncotarget, 8(1), 833-845 (2016-12-03)
Hedgehog (Hh) signaling plays important roles in embryonic development and in tumor formation. Apart from the well-established stimulation of the GLI family of transcription factors, Hh ligands promote the phosphorylation and activation of mTOR and AKT kinases, yet the molecular
Courtney Ackeifi et al.
JCI insight, 5(1) (2019-12-11)
Small molecule inhibitors of dual specificity, tyrosine phosphorylation-regulated kinase 1A (DYRK1A), including harmine and others, are able to drive human β cell regeneration. While DYRK1A is certainly a target of this class, whether it is the only or the most

我们的科学家团队拥有各种研究领域经验,包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.

联系技术服务部门