推荐产品
方案
≥98% (HPLC)
表单
powder
颜色
, white to yellow to light brown
溶解性
DMSO: 10 mg/mL, clear
储存温度
−20°C
SMILES字符串
CN1C2=CN=CC=C2C(C3=NC(NC4=C(OC)C=C(N5CCN(C)CC5)C=C4)=NC=C3)=C1
InChI
1S/C24H27N7O/c1-29-10-12-31(13-11-29)17-4-5-21(23(14-17)32-3)28-24-26-9-7-20(27-24)19-16-30(2)22-15-25-8-6-18(19)22/h4-9,14-16H,10-13H2,1-3H3,(H,26,27,28)
InChI key
ZYVXTMKTGDARKR-UHFFFAOYSA-N
生化/生理作用
AZ191 is a cell permeable, potent and selective inhibitor of DYRK1B that promotes a G1 cell cycle arrest.
AZ191 is a cell permeable, potent and selective inhibitor of DYRK1B.
其他说明
AZ191 has been expertly reviewed and recommended by the Chemical Probes Portal. For more information, please visit the AZ191 probe summary on the Chemical Probes Portal website.
储存分类代码
13 - Non Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
新产品
历史批次信息供参考:
ElShaddai Z White et al.
Scientific reports, 10(1), 12505-12505 (2020-07-29)
Inadequate nutrient intake leads to oxidative stress disrupting homeostasis, activating signaling, and altering metabolism. Oxidative stress serves as a hallmark in developing prostate lesions, and an aggressive cancer phenotype activating mechanisms allowing cancer cells to adapt and survive. It is
Courtney Ackeifi et al.
JCI insight, 5(1) (2019-12-11)
Small molecule inhibitors of dual specificity, tyrosine phosphorylation-regulated kinase 1A (DYRK1A), including harmine and others, are able to drive human β cell regeneration. While DYRK1A is certainly a target of this class, whether it is the only or the most
Rajeev Singh et al.
Oncotarget, 8(1), 833-845 (2016-12-03)
Hedgehog (Hh) signaling plays important roles in embryonic development and in tumor formation. Apart from the well-established stimulation of the GLI family of transcription factors, Hh ligands promote the phosphorylation and activation of mTOR and AKT kinases, yet the molecular
Devon R Blake et al.
Science signaling, 12(590) (2019-07-18)
Stabilization of the MYC oncoprotein by KRAS signaling critically promotes the growth of pancreatic ductal adenocarcinoma (PDAC). Thus, understanding how MYC protein stability is regulated may lead to effective therapies. Here, we used a previously developed, flow cytometry-based assay that
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