推荐产品
质量水平
方案
≥98% (HPLC)
表单
powder
旋光性
[α]/D -22 to -32°, c = 1 in H2O
储存条件
desiccated
颜色
white to beige
溶解性
H2O: 10 mg/mL, clear
储存温度
−20°C
SMILES字符串
O=C1N(C[C@H](NC)C2)C3=C2C=CC=C3N1.O=C(O)/C=C\C(O)=O
InChI
1S/C11H13N3O.C4H4O4/c1-12-8-5-7-3-2-4-9-10(7)14(6-8)11(15)13-9;5-3(6)1-2-4(7)8/h2-4,8,12H,5-6H2,1H3,(H,13,15);1-2H,(H,5,6)(H,7,8)/b;2-1-/t8-;/m1./s1
InChI key
VOJRMYBBPKNLLI-ORHWHDKWSA-N
应用
苏马尼罗马来酸酯已被用作多巴胺2型受体（D2R）激动剂，用于研究其对大鼠空间学习和记忆的影响。
生化/生理作用
Sumanirole是一种高度选择性的强效多巴胺D2受体激动剂，可降低黑质致密部中的血浆催乳素水平和降低的多巴胺神经元放电速率。Sumanirole在帕金森病动物模型中可有效刺激运动活动。
特点和优势
该化合物是神经科学研究推荐产品。点击此处 ，查看更多神经科学精选产品。想要了解有关生物活性小分子在其他研究领域应用的更多信息，请访问 sigma.com/discover-bsm。
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
从最新的版本中选择一种：
分析证书(COA)
Lot/Batch Number
Matthew F Lazenka et al.
The Journal of pharmacology and experimental therapeutics, 362(1), 14-23 (2017-04-16)
Clinically significant pain often includes a decrease in both behavior and mesolimbic dopamine signaling. Indirect and/or direct dopamine receptor agonists may alleviate pain-related behavioral depression. To test this hypothesis, the present study compared effects of indirect and direct dopamine agonists
Dopamine type 1-and 2-like signaling in the modulation of spatial reference learning and memory
Feyissa D D, et al.
Behavioural Brain Research, 362, 173-180 (2019)
Spatial working memory in male rats: pre-experience and task dependent roles of dopamine D1-and D2-like receptors
Bezu M, et al.
Frontiers in Behavioral Neuroscience, 11, 196-196 (2017)
L Lencesova et al.
Life sciences, 191, 186-194 (2017-10-22)
Haloperidol is an antipsychotic agent and acts as dopamine D2 receptor (D2R) antagonist, as a prototypical ligand of sigma1 receptors (Sig1R) and it increases expression of type 1 IP We used differentiated NG-108 cells and H9c2 cells. Gene expression, Western
Yasunori Haranishi et al.
Pharmacology, biochemistry, and behavior, 195, 172964-172964 (2020-06-07)
The descending serotonergic pathway, from the brainstem to spinal cord, modulates various aspects of pain processing. The spinal 5-hydroxytryptamine (5-HT)1A and 5-HT2A receptors play pivotal roles in pain modulation. Perospirone is a novel atypical antipsychotic that serves as a 5-hydroxytryptamine
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