质量水平
检测方案
≥97% (HPLC)
形式
powder
颜色
white to beige
溶解性
DMSO: 20 mg/mL, clear
储存温度
2-8°C
SMILES字符串
ClC1=C(Cl)C(C(C(CC)=C)=O)=CC=C1OCC(O)=O
InChI
1S/C13H12Cl2O4/c1-3-7(2)13(18)8-4-5-9(12(15)11(8)14)19-6-10(16)17/h4-5H,2-3,6H2,1H3,(H,16,17)
InChI key
AVOLMBLBETYQHX-UHFFFAOYSA-N
基因信息
human ... SLC12A1(6557)
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生化/生理作用
依他尼酸可增加苯丁酸氮芥对大鼠和人肿瘤细胞系的细胞毒性。
依他尼酸是非磺胺类环状利尿剂，用于治疗高血压和充血性心力衰竭等疾病引起的水肿。依他尼酸可阻断钠-钾-氯离子共同转运。此外，依他尼酸可强效抑制谷胱甘肽 S-转移酶家族成员。研究显示，依他尼酸可有效抑制包括肺癌和胰腺癌在内的癌细胞的 Tgase-2（转谷氨酰胺酶-2）依赖性转移。
警示用语：
Warning
危险声明
危险分类
Acute Tox. 4 Oral
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
Piriyaporn Thiendedsakul et al.
Veterinary world, 15(1), 46-54 (2022-04-05)
The crocodile is a model for studying relevant sources of environmental contamination. They were determined an appropriate biomonitoring species for various toxins. The cytosolic and microsomal fraction of crocodiles plays a role in detoxifying xenobiotics. Cytochrome P450 1A2 (CYP1A2) metabolizes
Maria Font Farre et al.
Plant & cell physiology, 65(1), 128-141 (2023-11-04)
Glutathione transferases (GSTs) represent a large and diverse enzyme family involved in the detoxification of small molecules by glutathione conjugation in crops, weeds and model plants. In this study, we introduce an easy and quick assay for photoaffinity labeling of
E Röth et al.
Experimental and clinical cardiology, 16(3), 92-96 (2011-11-09)
Oxidative stress and ischemia-reperfusion (I/R) injury are crucial in the pathogenesis of cardiovascular diseases. The antioxidant glutathione S-transferase (GST) is responsible for the high-capacity metabolic inactivation of electrophilic compounds and toxic substrates. The main objective of the present study was
Inhibition of rat and human glutathione S-transferase isoenzymes by ethacrynic acid and its glutathione conjugate.
Ploemen J H, et al.
Biochemical Pharmacology, 40(7), 1631-1635 (1990)
Ruina Wang et al.
Nature communications, 14(1), 5984-5984 (2023-09-27)
Induction of hypothermia during hibernation/torpor enables certain mammals to survive under extreme environmental conditions. However, pharmacological induction of hypothermia in most mammals remains a huge challenge. Here we show that a natural product P57 promptly induces hypothermia and decreases energy
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