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SML1083

利尿酸

Name: 利尿酸
Brand: SIGMA

≥97% (HPLC), glutathione S-transferase inhibitor, powder

别名:

2-[2,3-二氯-4-（2-亚甲基-1-氧丁基）苯氧基] 乙酸, ECA, [2,3-二氯-4-（2-乙基丙烯酰基）苯氧基] 乙酸, 依他尼酸, (2,3-二氯-4-[2-亚甲基丁酰]苯氧基)乙酸

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关于此项目

经验公式（希尔记法）:

C₁₃H₁₂Cl₂O₄

化学文摘社编号:

58-54-8

分子量:

303.14

NACRES:

NA.77

PubChem Substance ID:

329825461

UNSPSC Code:

12352106

EC Number:

200-384-1

MDL number:

MFCD00056693

Assay:

≥97% (HPLC)

Form:

powder

Quality level:

100

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属性

产品名称

利尿酸, ≥97% (HPLC)

Quality Level

100

assay

≥97% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 20 mg/mL, clear

storage temp.

2-8°C

SMILES string

ClC1=C(Cl)C(C(C(CC)=C)=O)=CC=C1OCC(O)=O

InChI

1S/C13H12Cl2O4/c1-3-7(2)13(18)8-4-5-9(12(15)11(8)14)19-6-10(16)17/h4-5H,2-3,6H2,1H3,(H,16,17)

InChI key

AVOLMBLBETYQHX-UHFFFAOYSA-N

Gene Information

human ... SLC12A1(6557)

说明

Biochem/physiol Actions

依他尼酸可增加苯丁酸氮芥对大鼠和人肿瘤细胞系的细胞毒性。

依他尼酸是非磺胺类环状利尿剂，用于治疗高血压和充血性心力衰竭等疾病引起的水肿。依他尼酸可阻断钠-钾-氯离子共同转运。此外，依他尼酸可强效抑制谷胱甘肽 S-转移酶家族成员。研究显示，依他尼酸可有效抑制包括肺癌和胰腺癌在内的癌细胞的 Tgase-2（转谷氨酰胺酶-2）依赖性转移。

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pictograms

GHS07

signalword

Warning

hcodes

H302

pcodes

P264 - P270 - P301 + P312 - P501

Hazard Classifications

Acute Tox. 4 Oral

存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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分析证书(COA)

Lot/Batch Number

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Effect of a glutathione S-transferase inhibitor on oxidative stress and ischemia-reperfusion-induced apoptotic signalling of cultured cardiomyocytes.

E Röth et al.

Experimental and clinical cardiology, 16(3), 92-96 (2011-11-09)

Oxidative stress and ischemia-reperfusion (I/R) injury are crucial in the pathogenesis of cardiovascular diseases. The antioxidant glutathione S-transferase (GST) is responsible for the high-capacity metabolic inactivation of electrophilic compounds and toxic substrates. The main objective of the present study was

Glutathione-S-transferase activity in various organs of Crocodylus siamensis and its attenuation role in aflatoxin B1-induced cell apoptosis in human hepatocarcinoma cells.

Piriyaporn Thiendedsakul et al.

Veterinary world, 15(1), 46-54 (2022-04-05)

The crocodile is a model for studying relevant sources of environmental contamination. They were determined an appropriate biomonitoring species for various toxins. The cytosolic and microsomal fraction of crocodiles plays a role in detoxifying xenobiotics. Cytochrome P450 1A2 (CYP1A2) metabolizes

Glutathione Transferase Photoaffinity Labeling Displays GST Induction by Safeners and Pathogen Infection.

Maria Font Farre et al.

Plant & cell physiology, 65(1), 128-141 (2023-11-04)

Glutathione transferases (GSTs) represent a large and diverse enzyme family involved in the detoxification of small molecules by glutathione conjugation in crops, weeds and model plants. In this study, we introduce an easy and quick assay for photoaffinity labeling of

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全球贸易项目编号

货号	GTIN
SML1083-10MG	04061837107566