所有图片(1)
别名:
γ-Glu-S-BzCys-PhGly二乙酯, TER 199, TER199, TLK199, Terrapin 199, （2S）-2-氨基-5-[[（（2R）-3-苄硫基-1-[[（1R）-2-乙氧基-2-氧-1-苯基乙基]氨基] -1-氧丙烷-2-基]氨基] -5-氧戊酸
经验公式（希尔记法）:
C27H35N3O6S
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质量水平
检测方案
≥98% (HPLC)
形式
powder
颜色
white to beige
溶解性
DMSO: 5 mg/mL, clear (warmed)
储存温度
2-8°C
InChI
1S/C27H35N3O6S/c1-3-35-26(33)21(28)15-16-23(31)29-22(18-37-17-19-11-7-5-8-12-19)25(32)30-24(27(34)36-4-2)20-13-9-6-10-14-20/h5-14,21-22,24H,3-4,15-18,28H2,1-2H3,(H,29,31)(H,30,32)/t21-,22-,24+/m0/s1
InChI key
GWEJFLVSOGNLSS-WPFOTENUSA-N
应用
Ezatiostat作为谷胱甘肽S-转移酶P1(GSTP1)抑制剂的应用实例：
- 研究其对新生大鼠睾丸性原细胞中过氧化物还原酶(PRDX6)抑制作用的影响
- 在蛋白水解分析中，用于支气管上皮细胞培养
- 研究其对肿瘤细胞中半胱氨酸-谷氨酸反向转运体xCT (SLC7A11)表达的影响
生化/生理作用
Ezatiostat是一种具有造血功能的谷胱甘肽-S-转移酶P1-1（GSTP1-1）的抑制剂。 细胞内脱酯后，ezatiostat的活性形式可结合并抑制GST P1-1，从而导致Jun激酶（JNK）的活化，Junk激酶是细胞生长和血液前体细胞分化的关键调节剂，从而恢复JNK和MAPK通路活性并促进MAPK介导的细胞增殖和分化。 Ezatiostat可促进造血前体细胞、粒细胞、单核细胞、红细胞和血小板的增殖和成熟。 Ezatiostat最近被指定为孤儿药，可用于治疗骨髓增生异常综合症。
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
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Redox biology, 26, 101256-101256 (2019-06-24)
Environmental proteases have been widely associated to the pathogenesis of allergic disorders. Der p 1, a cysteine-protease from house dust mite (HDM) Dermatophagoides pteronyssinus, constitutes one of the most clinically relevant indoor aeroallergens worldwide. Der p 1 protease activity depends
Sander Bekeschus et al.
Redox biology, 30, 101423-101423 (2020-01-14)
Cold physical plasma is a partially ionized gas investigated as a new anticancer tool in selectively targeting cancer cells in monotherapy or in combination with therapeutic agents. Here, we investigated the intrinsic resistance mechanisms of tumor cells towards physical plasma
Cristian O'Flaherty et al.
Antioxidants (Basel, Switzerland), 9(1) (2020-01-08)
Peroxiredoxins (PRDXs) are antioxidant enzymes that protect cells from oxidative stress and play a role in reactive oxygen species (ROS)-mediated signaling. We reported that PRDXs are critical for human fertility by maintaining sperm viability and regulating ROS levels during capacitation.
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