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质量水平
检测方案
≥98% (HPLC)
形式
powder
颜色
white to beige
溶解性
DMSO: 20 mg/mL, clear
储存温度
2-8°C
SMILES字符串
CN(C)C(NC1=CC=CC(C2=CC=C(N(C)C)C=C2)=C1)=O
InChI
1S/C17H21N3O/c1-19(2)16-10-8-13(9-11-16)14-6-5-7-15(12-14)18-17(21)20(3)4/h5-12H,1-4H3,(H,18,21)
InChI key
AWOPBSAJHCUSAS-UHFFFAOYSA-N
应用
阿格列汀是一种选择性助理甘油三酯胺酶抑制剂。
生化/生理作用
Atglistatin 是第一个选择性抑制脂肪甘油三酯脂肪酶 (ATGL) 的药物，ATGL 是参与从细胞甘油三酯储存库动员脂肪酸的限速酶。在大肠埃希菌中，Atglistatin 的IC50为0.7μM，对单甘油脂肪酶（MGL）、激素敏感性脂肪酶（HSL）或胰脂肪酶和脂蛋白脂肪酶PNPLA6和PNPLA7无活性。ATGL从细胞甘油三酸酯储存物中生成二酰基甘油，然后被激素敏感性脂肪酶（HSL）和甘油单酸酯脂肪酶降解为甘油和脂肪酸，从而促进了与胰岛素抵抗发展有关的脂毒性代谢产物的合成。 研究表明，Atglistatin抑制ATGL可减少“体外”和“体内”的脂肪酸动员。
其他说明
产品由格拉茨大学/格拉茨技术大学授权生产。
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
Phosphorylation of Beta-3 adrenergic receptor at serine 247 by ERK MAP kinase drives lipolysis in obese adipocytes.
Hong S, et al.
Molecular Metabolism (2018)
Xu Xiao et al.
Nature metabolism, 5(1), 165-181 (2023-01-17)
In cell models, changes in the 'accessible' pool of plasma membrane (PM) cholesterol are linked with the regulation of endoplasmic reticulum sterol synthesis and metabolism by the Aster family of nonvesicular transporters; however, the relevance of such nonvesicular transport mechanisms
Xirui Liu et al.
Molecular cancer, 17(1), 90-90 (2018-05-17)
Abnormal metabolism, including abnormal lipid metabolism, is a hallmark of cancer cells. Some studies have demonstrated that the lipogenic pathway might promote the development of hepatocellular carcinoma (HCC). However, the role of the lipolytic pathway in HCC has not been
Kacey J Prentice et al.
Journal of lipid research, 64(6), 100386-100386 (2023-05-13)
Levels of circulating fatty acid binding protein 4 (FABP4) protein are strongly associated with obesity and metabolic disease in both mice and humans, and secretion is stimulated by β-adrenergic stimulation both in vivo and in vitro. Previously, lipolysis-induced FABP4 secretion was found
Lena Pernas et al.
Cell metabolism, 27(4), 886-897 (2018-04-05)
How intracellular pathogens acquire essential non-diffusible host metabolites and whether the host cell counteracts the siphoning of these nutrients by its invaders are open questions. Here we show that host mitochondria fuse during infection by the intracellular parasite Toxoplasma gondii
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Discover Bioactive Small Molecules for Lipid Signaling Research
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