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SML1072

GSK-LSD1

Name: GSK-LSD1
Brand: SIGMA
Price: 385.39 CNY
Availability: InStock

≥98% (HPLC)

别名:

GSK-LSD1（反式外消旋）二盐酸盐, rel-N-[（1R，2S）-2-苯基环丙基] -4-哌啶胺盐酸盐（1：2）

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25 G

CN¥385.39

100 G

CN¥1,048.62

CN¥385.39

国内现货，预计发货时间April 23, 2025详情

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25 G

CN¥385.39

100 G

CN¥1,048.62

About This Item

经验公式（希尔记法）:

C₁₄H₂₀N₂ · 2HCl

CAS号:

1431368-48-7

分子量:

289.24

UNSPSC代码:

51111800

PubChem化学物质编号:

329825454

NACRES:

NA.77

CN¥385.39

国内现货，预计发货时间April 23, 2025详情

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此商品	40430	85520	47848
PHR1278 山梨酸钾	40430 山梨酸钾	85520 山梨酸钾	47848 山梨酸钾
technique(s) HPLC: suitable, gas chromatography (GC): suitable	technique(s) HPLC: suitable, gas chromatography (GC): suitable	technique(s) -	technique(s) HPLC: suitable, gas chromatography (GC): suitable
Quality Level 300	Quality Level 300	Quality Level 200	Quality Level 100
grade certified reference material, pharmaceutical secondary standard	grade certified reference material, TraceCERT^®	grade -	grade analytical standard
storage temp. 2-30°C	storage temp. -	storage temp. -	storage temp. 2-30°C
agency traceable to Ph. Eur. P2650000	agency -	agency -	agency -

应用

GSK-LSD1已用作小鼠中的赖氨酸特异性脱甲基酶 1（LSD1）抑制剂，用于研究败血症诱导的死亡率。[1]它还被用作抑制剂，用于研究苯乙肼激活人类免疫缺陷病毒（HIV）潜伏期是否由 LSD1 引起。[2]

生化/生理作用

GSK-LSD1 是赖氨酸特异性脱甲基酶 1 的有效选择性抑制剂。

GSK-LSD1 是赖氨酸特异性脱甲基酶 1（LSD1）的有效选择性抑制剂。GSK-LSD1 通过改变基因表达模式有效抑制不同癌细胞系的增殖。有关完整特征描述的详细信息，请访问 Structural Genomics Consortium（SGC）网站上的 GSK-LSD1 探针目录。

要了解用于表观遗传目标的其他 SGC 化学探针，请访问 sigma.com/sgc

特点和优势

GSK-LSD1 是一种表观遗传化学探针，是与 Structural Genomics Consortium (SGC) 合作研发的。想要了解更多信息并查看其他SGC表观遗传探针，请访问sigma.com/SGC。

这种化合物是基因调控研究的特色产品。点击此处发现更多特色基因调控产品。在sigma.com/discover-bsm可了解更多关于生物活性小分子的其他研究领域。

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(°F)

Not applicable

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Not applicable

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PKCα-LSD1-NF-κB-Signaling Cascade Is Crucial for Epigenetic Control of the Inflammatory Response

Kim D, et al.

Molecular Cell, 69(3), 398-411 (2018)

HIV-1 infection of microglial cells in a reconstituted humanized mouse model and identification of compounds that selectively reverse HIV latency

Llewellyn GN, et al.

Journal of Neurovirology, 1-12 (2017)

Lysine-specific demethylase 1A restricts ex vivo propagation of human HSCs and is a target of UM171.

Agatheeswaran Subramaniam et al.

Blood, 136(19), 2151-2161 (2020-06-26)

Culture conditions in which hematopoietic stem cells (HSCs) can be expanded for clinical benefit are highly sought after. Here, we report that inhibition of the epigenetic regulator lysine-specific histone demethylase 1A (LSD1) induces a rapid expansion of human cord blood-derived

Patterns of transcription factor programs and immune pathway activation define four major subtypes of SCLC with distinct therapeutic vulnerabilities.

Carl M Gay et al.

Cancer cell, 39(3), 346-360 (2021-01-23)

Despite molecular and clinical heterogeneity, small cell lung cancer (SCLC) is treated as a single entity with predictably poor results. Using tumor expression data and non-negative matrix factorization, we identify four SCLC subtypes defined largely by differential expression of transcription

Lysine specific demethylase 1 inactivation enhances differentiation and promotes cytotoxic response when combined with all-trans retinoic acid in acute myeloid leukemia across subtypes.

Kimberly N Smitheman et al.

Haematologica, 104(6), 1156-1167 (2018-12-06)

Lysine specific demethylase 1 (LSD1) is a histone modifying enzyme that suppresses gene expression through demethylation of lysine 4 on histone H3. The anti-tumor activity of GSK2879552 and GSK-LSD1, potent, selective irreversible inactivators of LSD1, has previously been described. Inhibition

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