SML1072
GSK-LSD1
≥98% (HPLC), lysine specific demethylase 1 (LSD1) inhibitor, powder
别名:
GSK-LSD1（反式外消旋） 二盐酸盐, rel-N-[（1R，2S）-2-苯基环丙基] -4-哌啶胺盐酸盐（1：2）
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选择尺寸
关于此项目
经验公式（希尔记法）:
C14H20N2 · 2HCl
化学文摘社编号:
分子量:
289.24
UNSPSC Code:
51111800
PubChem Substance ID:
NACRES:
NA.77
产品名称
GSK-LSD1, ≥98% (HPLC)
SMILES string
C1(N[C@@H]2C[C@H]2C3=CC=CC=C3)CCNCC1
InChI
1S/C14H20N2/c1-2-4-11(5-3-1)13-10-14(13)16-12-6-8-15-9-7-12/h1-5,12-16H,6-10H2/t13-,14+/m0/s1
InChI key
BASFYRLYJAZPPL-UONOGXRCSA-N
assay
≥98% (HPLC)
form
powder
color
white to beige
solubility
H2O: 20 mg/mL, clear
storage temp.
2-8°C
Quality Level
Application
GSK-LSD1已用作小鼠中的赖氨酸特异性脱甲基酶 1（LSD1）抑制剂，用于研究败血症诱导的死亡率。它还被用作抑制剂，用于研究苯乙肼激活人类免疫缺陷病毒（HIV）潜伏期是否由 LSD1 引起。
Biochem/physiol Actions
GSK-LSD1 是赖氨酸特异性脱甲基酶 1 的有效选择性抑制剂。
GSK-LSD1 是赖氨酸特异性脱甲基酶 1（LSD1）的有效选择性抑制剂。GSK-LSD1 通过改变基因表达模式有效抑制不同癌细胞系的增殖。有关完整特征描述的详细信息，请访问 Structural Genomics Consortium（SGC）网站上的 GSK-LSD1 探针目录。
要了解用于表观遗传目标的其他 SGC 化学探针，请访问 sigma.com/sgc
要了解用于表观遗传目标的其他 SGC 化学探针，请访问 sigma.com/sgc
Features and Benefits
GSK-LSD1 是一种表观遗传化学探针，是与 Structural Genomics Consortium (SGC) 合作研发的。想要了解更多信息并查看其他SGC表观遗传探针，请访问sigma.com/SGC。
这种化合物是基因调控研究的特色产品。点击此处发现更多特色基因调控产品。在sigma.com/discover-bsm可了解更多关于生物活性小分子的其他研究领域。
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
HIV-1 infection of microglial cells in a reconstituted humanized mouse model and identification of compounds that selectively reverse HIV latency
Llewellyn GN, et al.
Journal of Neurovirology, 1-12 (2017)
PKCα-LSD1-NF-κB-Signaling Cascade Is Crucial for Epigenetic Control of the Inflammatory Response
Kim D, et al.
Molecular Cell, 69(3), 398-411 (2018)
Lysine-specific demethylase 1A restricts ex vivo propagation of human HSCs and is a target of UM171.
Agatheeswaran Subramaniam et al.
Blood, 136(19), 2151-2161 (2020-06-26)
Culture conditions in which hematopoietic stem cells (HSCs) can be expanded for clinical benefit are highly sought after. Here, we report that inhibition of the epigenetic regulator lysine-specific histone demethylase 1A (LSD1) induces a rapid expansion of human cord blood-derived
Carl M Gay et al.
Cancer cell, 39(3), 346-360 (2021-01-23)
Despite molecular and clinical heterogeneity, small cell lung cancer (SCLC) is treated as a single entity with predictably poor results. Using tumor expression data and non-negative matrix factorization, we identify four SCLC subtypes defined largely by differential expression of transcription
Kimberly N Smitheman et al.
Haematologica, 104(6), 1156-1167 (2018-12-06)
Lysine specific demethylase 1 (LSD1) is a histone modifying enzyme that suppresses gene expression through demethylation of lysine 4 on histone H3. The anti-tumor activity of GSK2879552 and GSK-LSD1, potent, selective irreversible inactivators of LSD1, has previously been described. Inhibition
商品
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