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质量水平
方案
≥98% (HPLC)
表单
powder
颜色
white to light brown
溶解性
DMSO: 10 mg/mL, clear
储存温度
2-8°C
SMILES字符串
S=C(N\N=C\c1c(cc(cc1)O)O)NC(C)(C)C
InChI
1S/C12H17N3O2S/c1-12(2,3)14-11(18)15-13-7-8-4-5-9(16)6-10(8)17/h4-7,16-17H,1-3H3,(H2,14,15,18)/b13-7+
InChI key
LTFUAYRGVLQXKC-NTUHNPAUSA-N
应用
IMM-01 has been used as a formin activator to study its effects on motor neurons (MNs).
生化/生理作用
IMM-01 binds and activates formin thereby leading to autoinhinition.
IMM-01 is an agonist of the mammalian Diaphanous (mDia)-related formins that triggers actin assembly and microtubule stabilization, serum response factor-mediated gene expression, cell-cycle arrest, and apoptosis. IMM-01 inhibits DID–DAD binding, which in turn activates mDia family of formins in cells. IMM-01 slows tumor growth in a mouse xenograft model of colon cancer.
IMM-01 is an agonist of the mammalian Diaphanous (mDia)-related formins that triggers actin assembly.
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
历史批次信息供参考:
分析证书(COA)
Lot/Batch Number
Anthony Giampetruzzi et al.
Nature communications, 10(1), 3827-3827 (2019-08-25)
Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease of unknown etiology. Although defects in nucleocytoplasmic transport (NCT) may be central to the pathogenesis of ALS and other neurodegenerative diseases, the molecular mechanisms modulating the nuclear pore function are still
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