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质量水平
检测方案
≥98% (HPLC)
形式
powder
颜色
white to beige
溶解性
DMSO: 10 mg/mL, clear (warmed)
储存温度
2-8°C
InChI
1S/C14H11NOS/c1-10-6-8-11(9-7-10)15-14(16)12-4-2-3-5-13(12)17-15/h2-9H,1H3
InChI key
KRXMYBAZKJBJAB-UHFFFAOYSA-N
生化/生理作用
S,S′-1,4-亚苯基双(1,2-乙二基)双异硫脲(PBIT)是一种 iNOS(诱导型一氧化氮合酶)抑制剂。它能够抑制JARIDB1 高表达的乳腺癌细胞系的增殖。
PBIT 是 JARID1B(KDM5B)组蛋白赖氨酸脱甲基酶的有效抑制剂,可抑制 UACC-812 细胞中 H3K4me3 的去除。PBIT 抑制过表达 JARID1B 的细胞的增殖。PBIT 对 JARID1 酶具有选择性,并且不抑制 UTX 或 JMJD3 脱甲基酶。
特点和优势
这种化合物是基因调控研究的特色产品。点击此处发现更多特色基因调控产品。在sigma.com/discover-bsm可了解更多关于生物活性小分子的其他研究领域。
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
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商品
We offer a variety of small molecule research tools, such as transcription factor modulators, inhibitors of chromatin modifying enzymes, and agonists/antagonists for target identification and validation in gene regulation research; a selection of these research tools is shown below.
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