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主要文件

COO原产地证书/COA分析证书

安全信息

安全和法规

SML1051

比伐卢定三氟乙酸盐

Name: 比伐卢定 三氟乙酸盐
Brand: SIGMA

≥97% (HPLC)

别名:

Hirulog 三氟乙酸盐, 三氟醋酸比伐卢定

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About This Item

经验公式（希尔记法）:

C₉₈H₁₃₈N₂₄O₃₃ · xC₂HF₃O₂

CAS号:

128270-60-0

分子量:

2180.29 (free base basis)

UNSPSC代码:

51111800

NACRES:

NA.77

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USP

1076013

Bivalirudin

CLS432006

Corning^® CoolCell^™ FTS30

Sigma-Aldrich

G8048

GLP-1R 激动剂

Sigma-Aldrich

D2650

二甲基亚砜

USP

1076035

[des-Glu13]-Bivalirudin

Sigma-Aldrich

A0487

阿加曲班一水合物

Sigma-Aldrich

SML2370

Dabigatran

Sigma-Aldrich

G8147

胰高血糖素样肽 Ⅰ 酰胺片段 7-36 人

Sigma-Aldrich

G9416

Glucagon-Like Peptide 1 Fragment 7-37 human

Sigma-Aldrich

SML3285

Apixaban

质量水平

100

方案

≥97% (HPLC)

表单

powder

颜色

white to off-white

运输

wet ice

储存温度

−20°C

SMILES字符串

N5([C@@H](CCC5)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc6ccc(cc6)O)C(=O)N[C@@H](CC(C)C)C(=O)O)C(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)CNC(=O)[C@@H](NC(=O)CNC(=O)CNC(=O)CNC(=O)CNC(=O)[C@H]2N(CCC2)C(=O)[C@@H](

InChI

1S/C98H138N24O33/c1-5-52(4)82(96(153)122-39-15-23-70(122)92(149)114-60(30-34-79(134)135)85(142)111-59(29-33-78(132)133)86(143)116-64(43-55-24-26-56(123)27-25-55)89(146)118-67(97(154)155)40-51(2)3)119-87(144)61(31-35-80(136)137)112-84(141)58(28-32-77(130)131)113-88(145)63(42-54-18-10-7-11-19-54)117-90(147)66(45-81(138)139)110-76(129)50-107-83(140)65(44-71(100)124)109-75(128)49-106-73(126)47-104-72(125)46-105-74(127)48-108-91(148)68-21-13-38-121(68)95(152)62(20-12-36-103-98(101)102)115-93(150)69-22-14-37-120(69)94(151)57(99)41-53-16-8-6-9-17-53/h6-11,16-19,24-27,51-52,57-70,82,123H,5,12-15,20-23,28-50,99H2,1-4H3,(H2,100,124)(H,104,125)(H,105,127)(H,106,126)(H,107,140)(H,108,148)(H,109,128)(H,110,129)(H,111,142)(H,112,141)(H,113,145)(H,114,149)(H,115,150)(H,116,143)(H,117,147)(H,118,146)(H,119,144)(H,130,131)(H,132,133)(H,134,135)(H,136,137)(H,138,139)(H,154,155)(H4,101,102,103)/t52-,57+,58-,59-,60-,61-,62-,63-,64-,65-,66-,67-,68-,69-,70-,82-/m0/s1

InChI key

OIRCOABEOLEUMC-GEJPAHFPSA-N

生化/生理作用

比伐卢定三氟乙酸盐是由20个氨基酸组成的合成肽。它可作为抗凝剂，用于经冠状动脉成形术的患有不稳定型心绞痛患者。

比伐卢定是一种特异性且可逆的二价直接凝血酶抑制剂。

比伐卢定是一种特异性且可逆的二价直接凝血酶抑制剂。比伐卢定与凝血酶（循环的和凝块结合的)的催化位点和阴离子结合的外位点均有特异性结合。

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

法规信息

常规特殊物品

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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Critical Appraisal of Bivalirudin versus Heparin for Percutaneous Coronary Intervention: A Meta-Analysis of Randomized Trials.

Anthony A Bavry et al.

PloS one, 10(5), e0127832-e0127832 (2015-05-27)

Percutaneous coronary intervention with bivalirudin plus bail-out glycoprotein IIb/IIIa inhibitors has been shown to be as effective as unfractionated heparin plus routine glycoprotein IIb/IIIa inhibitors in preventing cardiac ischemic events, but with a lower bleeding risk. It is unknown whether

Bivalirudin versus heparin with or without glycoprotein IIb/IIIa inhibitors in patients with STEMI undergoing primary percutaneous coronary intervention: pooled patient-level analysis from the HORIZONS-AMI and EUROMAX trials.

Gregg W Stone et al.

Journal of the American College of Cardiology, 65(1), 27-38 (2015-01-13)

In the HORIZONS-AMI (Harmonizing Outcomes with RevasculariZatiON and Stents in Acute Myocardial Infarction) trial, 3,602 patients undergoing primary percutaneous coronary intervention (PCI) for ST-segment elevation myocardial infarction (STEMI) treated with bivalirudin had lower bleeding and mortality rates, but higher acute

Bivalirudin versus heparin in patients planned for percutaneous coronary intervention: a meta-analysis of randomised controlled trials.

Matthew A Cavender et al.

Lancet (London, England), 384(9943), 599-606 (2014-08-19)

Bivalirudin is an alternative to heparin in patients undergoing percutaneous coronary intervention (PCI). We aimed to define the effects of a bivalirudin-based anticoagulation regimen compared with a heparin-based anticoagulation regimen on ischaemic and bleeding outcomes. We searched Medline, the Cochrane

Nucleic Acid Ligands With Protein-like Side Chains: Modified Aptamers and Their Use as Diagnostic and Therapeutic Agents.

John C Rohloff et al.

Molecular therapy. Nucleic acids, 3, e201-e201 (2014-10-08)

Limited chemical diversity of nucleic acid libraries has long been suspected to be a major constraining factor in the overall success of SELEX (Systematic Evolution of Ligands by EXponential enrichment). Despite this constraint, SELEX has enjoyed considerable success over the

Bivalirudin Versus Heparin Plus Glycoprotein IIb/IIIa Inhibitors in Patients with Diabetes Mellitus Undergoing Percutaneous Coronary Intervention: A Meta-Analysis of Randomized Controlled Trials.

Uzoma N Ibebuogu et al.

American journal of cardiovascular drugs : drugs, devices, and other interventions, 15(4), 275-285 (2015-03-19)

Diabetes mellitus (DM) is a pro-thrombotic state with enhanced thrombin generation and platelet reactivity. For most patients undergoing percutaneous coronary intervention (PCI), bivalirudin demonstrates efficacy comparable with that of heparin and glycoprotein IIb/IIIa inhibitors (GPIs). Yet, because of their pro-thrombotic

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比伐卢定三氟乙酸盐