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Merck
CN
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主要文件

安全信息

SML1018

Sigma-Aldrich

Cyclosporin A

≥95% (HPLC), DMSO solution, calcineurin inhibitor

别名:

CsA, 环孢霉素

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About This Item

经验公式（希尔记法）:
C62H111N11O12
CAS号:
59865-13-3
分子量:
1202.61
EC 号:
200-664-3
UNSPSC代码:
12352200
NACRES:
NA.77

产品名称

环孢素A，即用型溶液, 1 mg/mL in DMSO

表单

DMSO solution

质量水平

200

储存条件

protect from light

浓度

1 mg/mL in DMSO

运输

dry ice

储存温度

−20°C

SMILES字符串

N1(C(C(=O)NC(C(=O)N(CC(=O)N(C(C(=O)NC(C(=O)N(C(C(=O)NC(C(=O)NC(C(=O)N(C(C(=O)N(C(C(=O)N(C(C1=O)C(C)C)C)CC(C)C)C)CC(C)C)C)C)C)CC(C)C)C)C(C)C)CC(C)C)C)C)CC)C(O)C(C\C=C\C)C)C

InChI

1S/C62H111N11O12/c1-25-27-28-40(15)52(75)51-56(79)65-43(26-2)58(81)67(18)33-48(74)68(19)44(29-34(3)4)55(78)66-49(38(11)12)61(84)69(20)45(30-35(5)6)54(77)63-41(16)53(76)64-42(17)57(80)70(21)46(31-36(7)8)59(82)71(22)47(32-37(9)10)60(83)72(23)50(39(13)14)62(85)73(51)24/h25,27,34-47,49-52,75H,26,28-33H2,1-24H3,(H,63,77)(H,64,76)(H,65,79)(H,66,78)/b27-25+

InChI key

PMATZTZNYRCHOR-IMVLJIQESA-N

应用

环孢素A已用于研究其对3D近端肾小管灌注模型的毒性作用。

生化/生理作用

环孢素A(cyclosporin A)通常在移植术后给药，用于抗排斥反应。在对器官移植起效之外，环孢素A(CyA)也会带来肾毒性副作用。
环孢素A(cyclosporin A, CsA)是由多孔木霉(Tolypocladium inflatum)真菌合成的非极性环状多肽。它是一种强效的免疫抑制剂，主要作用于T淋巴细胞，已证明可在mRNA转录水平抑制多种核蛋白的T细胞活化作用。 它可与胞内受体亲环素形成复合物，复合物可结合一种钙离子/钙调依赖性蛋白磷酸酶——钙调神经磷酸酶(calcineurin)，抑制其酶活性。 CsA可抑制培养肝细胞中丙型肝炎病毒基因组的复制。 > 10 nM浓度的CsA可保护肝细胞免遭鬼笔环肽破坏。 CsA可通过抑制钙调神经磷酸酶抑制T细胞活化生产 IL2 。
有大量引用本品的文献报道，包括对于其分析特性的全面综述。

其他说明

光敏感

储存分类代码

10 - Combustible liquids

WGK

WGK 1

闪点(°F)

188.6 °F - closed cup

闪点(°C)

87 °C - closed cup

法规信息

常规特殊物品

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分析证书(COA)

Lot/Batch Number
0000287844
0000263481
0000241680
0000234113
0000287844

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