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质量水平
方案
≥98% (HPLC)
表单
powder
颜色
white to beige
溶解性
DMSO: 10 mg/mL, clear
储存温度
2-8°C
SMILES字符串
n1ccc(cc1)C(=O)\C=C\c2nc3c(cc2)cccc3
InChI
1S/C17H12N2O/c20-17(14-9-11-18-12-10-14)8-7-15-6-5-13-3-1-2-4-16(13)19-15/h1-12H/b8-7+
InChI key
UJJUKZPBUMCSJZ-BQYQJAHWSA-N
应用
PFK15，一种 PFKFB3 抑制剂，已用于研究其对横纹肌肉瘤（RD）细胞自噬和增殖的调节作用。
生化/生理作用
PFK15 也称为 1-（4-吡啶基）-3-（2-喹啉基）-2-丙烯-1-酮。它可以防止横纹肌肉瘤的细胞自噬和繁殖。PFK15 通过线粒体途径导致胃癌细胞死亡。它还在体内阻断 MKN45（人胃癌细胞系）肿瘤的生长。PFK15 促进细胞周期停滞，并改变关键细胞周期蛋白的上调。
PFK15 是 PFKB3（6-磷酸果糖-2-激酶/果糖-2,6-双磷酸酶 3）的高效和选择性拮抗剂，可导致癌细胞和转化的细胞快速凋亡。PFK15 抑制 LLC 异种移植物的生长。
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
从最新的版本中选择一种：
分析证书(COA)
Lot/Batch Number
PFK15, a small molecule inhibitor of PFKFB3, induces cell cycle arrest, apoptosis and inhibits invasion in gastric cancer.
Zhu W, et al.
PLoS ONE, 11(9), e0163768-e0163768 (2016)
PFK15, a PFKFB3 antagonist, inhibits autophagy and proliferation in rhabdomyosarcoma cells.
Wang C, et al.
International Journal of Molecular Medicine, 42(1), 359-367 (2018)
Lingyan Jiang et al.
Nature communications, 12(1), 879-879 (2021-02-11)
Salmonella Typhimurium establishes systemic infection by replicating in host macrophages. Here we show that macrophages infected with S. Typhimurium exhibit upregulated glycolysis and decreased serine synthesis, leading to accumulation of glycolytic intermediates. The effects on serine synthesis are mediated by
Siyuan Yan et al.
Oncotarget, 8(46), 80909-80922 (2017-11-09)
6-Phosphofructo-2-kinase/fructose-2,6-bisphosphatase isoform 3 (PFKFB3), is a critical enzyme for glycolysis and highly expressed in cancer cells. It plays an essential role in regulating metabolism, angiogenesis, and inflammation. Although PFKFB3 is involved in modulating autophagy, its regulatory role appears to be
Q Lu et al.
Cell death & disease, 6, e2005-e2005 (2015-12-04)
Rasfonin is a fungal secondary metabolite with demonstrated antitumor effects. However, the underlying mechanism of the regulatory role in autophagy initiated by rasfonin is largely unknown. Moreover, the function of Akt to positively mediate the induced autophagy remains elusive. In
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