所有图片(1)
别名:
2-[(4-Bromophenyl)methylene]-N-(2,6-dimethylphenyl)-hydrazinecarboxamide
经验公式（希尔记法）:
C16H16BrN3O
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生化/生理作用
EGA is a small molecule that blocks the entry of anthrax lethal toxin by inhibiting trafficking pathways in acidified endosomes, without affecting endosome pH. EGA blocks trafficking of other toxins, including diphtheria toxin, but does not inhibit trafficking of ricin. The compound EGA attenuates lysosomal targeting and degradation of the EGF receptor, but does not block does not block endosomal recycling of transferrin.
特点和优势
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WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
Samuel J Dobson et al.
Antiviral research, 179, 104819-104819 (2020-05-12)
During virus entry, members of the Polyomaviridae transit the endolysosomal network en route to the endoplasmic reticulum (ER), from which degraded capsids escape into the cytoplasm and enter the nucleus. Emerging evidence suggests that viruses require both endosomal acidification and
Yu Wu et al.
The FEBS journal, 287(15), 3184-3199 (2020-01-05)
The endo-lysosome system is involved in endocytosis, protein sorting, and degradation as well as autophagy. Numerous toxins and pathogens exploit this system to enter host cells and exert their deleterious effects. Modulation of host endo-lysosome pathway may restrict multiple toxins
商品
Cyclic nucleotides like cAMP modulate cell function via PKA activation and ion channels.
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