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主要文件

COO原产地证书/COA分析证书

安全信息

安全和法规

SML0996

Ospemifene

Name: Ospemifene
Brand: SIGMA

≥98% (HPLC)

别名:

(deaminohydroxy)toremifene, 2-[4-[(1Z)-4-Chloro-1,2-diphenyl-1-buten-1-yl]phenoxy]ethanol, FC-1271a

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About This Item

经验公式（希尔记法）:

C₂₄H₂₃ClO₂

CAS号:

128607-22-7

分子量:

378.89

UNSPSC代码:

51111800

NACRES:

NA.77

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OLIGO

定制DNA寡核苷酸

Sigma-Aldrich

901967

Nanodiamonds

PROBES

Custom qPCR Probes

Sigma-Aldrich

T7204

Toremifene citrate salt

Y0000149

Rifabutin

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Hydrocodone

Sigma-Aldrich

SML2217

Parecoxib sodium

Sigma-Aldrich

T5648

泰莫西芬

Sigma-Aldrich

MAK124

白蛋白检测试剂盒（BCG法）

Supelco

C6272

克罗米酚柠檬酸盐

质量水平

100

方案

≥98% (HPLC)

表单

powder

颜色

white to beige

溶解性

DMSO: 20 mg/mL, clear

储存温度

2-8°C

SMILES字符串

ClCC\C(=C(\c3ccc(cc3)OCCO)/c2ccccc2)\c1ccccc1

InChI

1S/C24H23ClO2/c25-16-15-23(19-7-3-1-4-8-19)24(20-9-5-2-6-10-20)21-11-13-22(14-12-21)27-18-17-26/h1-14,26H,15-18H2/b24-23-

InChI key

LUMKNAVTFCDUIE-VHXPQNKSSA-N

生化/生理作用

Ospemifene is a selective estrogen receptor modulator (SERM), a metabolite of toremifene, with a unique estrogen agonist/antagonist tissue profile. Ospemifene was recently approved in the US for the treatment of dyspareunia associated with vulvar and vaginal atrophy in postmenopausal women, and is being investigated for the treatment and prevention of osteoporosis and breast cancer. Ospemifene binds ERα and ERβ with approximately equal affinities with IC₅₀ values for estrogen receptor (ER) α and β of 0.8 μM and 1.7 μM, respectively. Ospemifene has estrogen-like effects on the vaginal epithelium and bone, antiproliferative effects in breast, and a neutral endometrial profile.