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主要文件

COO原产地证书/COA分析证书

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安全信息

安全和法规

SML0950

盐酸美克洛嗪

Name: 盐酸美克洛嗪
Brand: SIGMA

≥97% (HPLC)

别名:

1-(p-Chloro-α-phenylbenzyl)-4-(m-methylbenzyl)-piperazine dihydrochloride, 1-[(4-Chlorophenyl)phenylmethyl]4-[?(3-methylphenyl)methyl]piperazine dihydrochloride, NSC 28728

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About This Item

经验公式（希尔记法）:

C₂₅H₂₇ClN₂ · 2HCl

CAS号:

1104-22-9

分子量:

463.87

EC 号:

214-164-8

UNSPSC代码:

12352200

NACRES:

NA.77

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盐酸美克洛嗪

M0220000

Meclozine dihydrochloride

Supelco

PHR3571

Meclizine Hydrochloride

USP

1377009

Meclizine hydrochloride

Supelco

PHR2654

磺胺嘧啶银(I)

Supelco

PHR1012

对羟基苯甲酸甲酯

PH009750

1-[(4-chlorophenyl)(phenyl)methyl]-4-(3-methylbenzyl)piperazine

Supelco

92091

33种周期表ICP混标1

Supelco

PHR1607

羟嗪

Supelco

PHR1010

羟苯丙酯

质量水平

100

方案

≥97% (HPLC)

表单

powder

储存条件

desiccated

颜色

white to beige

溶解性

DMSO: 5 mg/mL, clear (warmed)

储存温度

2-8°C

SMILES字符串

[Cl-].[Cl-].Clc1ccc(cc1)C(N3CCN(CC3)Cc4cc(ccc4)C)c2ccccc2.[H+].[H+]

InChI

1S/C25H27ClN2.2ClH/c1-20-6-5-7-21(18-20)19-27-14-16-28(17-15-27)25(22-8-3-2-4-9-22)23-10-12-24(26)13-11-23;;/h2-13,18,25H,14-17,19H2,1H3;2*1H

InChI key

VCTHNOIYJIXQLV-UHFFFAOYSA-N

生化/生理作用

Meclizine has the ability to increase glycolysis and decrease cellular ATP levels in media that has glucose and galactose. It guards the kidney against ischemia-reperfusion injury. Meclizine is considered as an anti-nausea and anti-dizziness drug, was identified in a ′nutrient-sensitized′ chemical screen. In human, it acts as an agonist of pregnane X receptor (PXR). It enhances the expression of CYP3A4 (cytochrome P450 3A4) mRNA and reduces CYP3A-catalyzed testosterone 6β-hydroxylation in primary cultures of human hepatocytes.

Meclizine is a potent histamine H1 receptor antagonist that is widely used as antiemetic. Recently, meclizine was identified as an inhibitor of hepstin. Also, meclizine is a potent inhibitor of mitochondrial respiration through inhibition of cytosolic CTP:phosphoethanolamine cytidylyltransferase (Pcyt2).

特点和优势

This compound is a featured product for Neuroscience research. Click here to discover more featured Neuroscience products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.