推荐产品
质量水平
方案
≥98% (HPLC)
表单
powder
颜色
white to beige
溶解性
DMSO: >5 mg/mL, clear
储存温度
room temp
SMILES字符串
FC(F)(F)c1cc(ccc1)c2nc3c(c(c2CN6CCC(CC6)N7CCCCC7)C(=O)NC5(CC5)c4ccccc4)ccc(c3)Br
InChI
1S/C37H38BrF3N4O/c38-28-12-13-30-32(23-28)42-34(25-8-7-11-27(22-25)37(39,40)41)31(24-44-20-14-29(15-21-44)45-18-5-2-6-19-45)33(30)35(46)43-36(16-17-36)26-9-3-1-4-10-26/h1,3-4,7-13,22-23,29H,2,5-6,14-21,24H2,(H,43,46)
InChI key
UIVOZBSCHXCGPS-UHFFFAOYSA-N
应用
GSK2193874作为瞬时受体电位香草醛4(TRPV4)拮抗剂的应用实例：
- 研究其对小鼠中GSK101诱导的结肠收缩的影响
- 研究其对鼠骨密质来源成骨细胞(CB-OB)的影响
- 研究其对小鼠中脂多糖(LPS)所致肺损伤的影响
生化/生理作用
GSK2193874 是 TRPV4 离子通道 (IC50 = 50 nM) 的一种非常有效的特异性拮抗剂。TRPV4 活性可驱动高肺静脉压 (PVP) 引起的肺水肿。GSK2193874 可阻断表达天然和重组 TRPV4 的细胞中的 TRPV4 介导钙内流，并抑制 PVP 症状啮齿动物和犬肺中的血管透性和肺水肿。该化合物还可修复心肌梗塞模型小鼠体内的肺水肿。
警示用语：
Danger
危险分类
Acute Tox. 3 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
靶器官
Respiratory system
储存分类代码
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
从最新的版本中选择一种：
分析证书(COA)
Lot/Batch Number
Jialie Luo et al.
Immunity, 49(1), 107-119 (2018-07-01)
Intestinal macrophages are critical for gastrointestinal (GI) homeostasis, but our understanding of their role in regulating intestinal motility is incomplete. Here, we report that CX3C chemokine receptor 1-expressing muscularis macrophages (MMs) were required to maintain normal GI motility. MMs expressed the
Sheikh Rayees et al.
Cell reports, 27(3), 793-805 (2019-04-18)
Alveolar macrophages (AMs), upon sensing pathogens, trigger host defense by activating toll-like receptor 4 (TLR4), but the counterbalancing mechanisms that deactivate AM inflammatory signaling and prevent lethal edema, the hallmark of acute lung injury (ALI), remain unknown. Here, we demonstrate
Elena Cambria et al.
Cells, 9(7) (2020-07-28)
Mechanical loading and inflammation interact to cause degenerative disc disease and low back pain (LBP). However, the underlying mechanosensing and mechanotransductive pathways are poorly understood. This results in untargeted pharmacological treatments that do not take the mechanical aspect of LBP
Tomasz Janczi et al.
Cells, 10(10) (2021-10-24)
Mechanotransduction is elicited in cells upon the perception of physical forces transmitted via the extracellular matrix in their surroundings and results in signaling events that impact cellular functions. This physiological process is a prerequisite for maintaining the integrity of diarthrodial
Nicholas Mikolajewicz et al.
eLife, 7 (2018-10-17)
Bone cells sense and actively adapt to physical perturbations to prevent critical damage. ATP release is among the earliest cellular responses to mechanical stimulation. Mechanical stimulation of a single murine osteoblast led to the release of 70 ± 24 amole
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