所有图片(1)
别名:
(Z)-2-氰基-3-羟基-N- [4-（三氟甲基）苯基]-2-丁烯酰胺, A 1726, A77-1726, A771726, HMR 1726, N-（4-三氟甲基苯基）-2-氰基-3-羟基克罗胺, SU 20, 氟酰胺
经验公式（希尔记法）:
C12H9F3N2O2
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质量水平
检测方案
≥98% (HPLC)
形式
powder
颜色
white to beige
溶解性
DMSO: 5 mg/mL, clear (warmed)
储存温度
−20°C
InChI
1S/C12H9F3N2O2/c1-7(18)10(6-16)11(19)17-9-4-2-8(3-5-9)12(13,14)15/h2-5,18H,1H3,(H,17,19)/b10-7-
InChI key
UTNUDOFZCWSZMS-YFHOEESVSA-N
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应用
特立氟胺是一种二氢乳清酸脱氢酶 (DHODH) 抑制剂。
生化/生理作用
特立氟胺是一种可口服的抗炎免疫调节剂。阻断二氢乳清酸脱氢酶的活性，阻止嘧啶合成及 T、B 细胞增殖和功能。特立氟胺用于治疗风湿性关节炎，最近被批准用于多发性硬化症。
警示用语：
Warning
危险声明
危险分类
Acute Tox. 4 Oral
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
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Bicuspid aortic valve (BAV) is the most common congenital cardiovascular disease in general population and is frequently associated with the development of thoracic aortic aneurysm (TAA). There is no effective strategy to intervene with TAA progression due to an incomplete
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The synthesis of a series of novel 7-aminooxazolo[5,4-d]pyrimidines 5, transformations during their synthesis and their physicochemical characteristics have been described. Complete detailed spectral analysis of the intermediates 2-4, the N'-cyanooxazolylacetamidine by-products 7 and final compounds 5 has been carried out
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Molecular cancer therapeutics, 18(1), 3-16 (2018-10-26)
PTC299 was identified as an inhibitor of VEGFA mRNA translation in a phenotypic screen and evaluated in the clinic for treatment of solid tumors. To guide precision cancer treatment, we performed extensive biological characterization of the activity of PTC299 and
Zhen-Guo Ma et al.
Clinical science (London, England : 1979), 132(6), 685-699 (2018-03-16)
T-cell infiltration and the subsequent increased intracardial chronic inflammation play crucial roles in the development of cardiac hypertrophy and heart failure (HF). A77 1726, the active metabolite of leflunomide, has been reported to have powerful anti-inflammatory and T cell-inhibiting properties.
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Bioactive small molecules for immune system signaling target identification/validation and antibiotics, antivirals, and antifungals offered.
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