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质量水平
方案
≥98% (HPLC)
表单
powder
颜色
off-white to gray-brown
溶解性
DMSO: 10 mg/mL, clear
储存温度
−20°C
SMILES字符串
N(Cc4[o]c(cc4)C)c1ncnc2c1cc(cc2)c3[o]c(cc3)CO
InChI
1S/C19H17N3O3/c1-12-2-4-14(24-12)9-20-19-16-8-13(3-6-17(16)21-11-22-19)18-7-5-15(10-23)25-18/h2-8,11,23H,9-10H2,1H3,(H,20,21,22)
InChI key
ROCFOIBAEVAOLQ-UHFFFAOYSA-N
生化/生理作用
ML167 is the first highly selective inhibitor of of Cdc2-like kinase 4 (Clk4) with an IC50 of 136 nM for Clk4, >10-fold selectivity for closely related kinases Clk1-3 and Dyrk1A/1B, and minimal activity against a panel of other kinases tested. The Cdc2-like kinases (Clk′s) and the dual-specificity tyrosine phosphorylation-regulated kinases (Dyrk′s) are involved in regulation of gene splicing. The Cdc2-like kinases phosphorylate the serine/arginine-rich (SR) proteins, a major component of the spliceosome.
警示用语：
Warning
危险声明
危险分类
Acute Tox. 4 Oral
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
新产品
从最新的版本中选择一种：
分析证书(COA)
Lot/Batch Number
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