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Merck
CN

SML0907

Sigma-Aldrich

Apoptolidin A Ready Made Solution

1 mg/mL in DMSO

别名:

Apoptolidin, FU 40A

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About This Item

经验公式(希尔记法):
C58H96O21
分子量:
1129.37
EC 号:
UNSPSC代码:
12352200
PubChem化学物质编号:
NACRES:
NA.77

生物来源

Amycolatopsis sp.

质量水平

表单

DMSO solution

浓度

1 mg/mL in DMSO

抗生素抗菌谱

fungi

作用机制

enzyme | inhibits

运输

dry ice

储存温度

−20°C

SMILES字符串

CC(/C=C1\C)=C\C(C)=C\[C@@H](C)[C@H](O[C@H]2[C@@H](O)[C@H](O)[C@@H](OC)[C@H](C)O2)/C=C/C(C)=C/CC[C@H](O)[C@@H](OC)CC([C@H]([C@]3([C@H](C)[C@@H](O)[C@@H](C)C(C[C@H](COC)O[C@H]4C[C@@](O)(C)[C@@H](O[C@H]5C[C@@H](OC)[C@H](O)[C@H](C)O5)[C@H](C)O4)O3)O)O)OC1=O

InChI

1S/C58H96O21/c1-29-17-16-18-40(59)43(69-13)25-45(76-55(65)33(5)23-31(3)21-30(2)22-32(4)41(20-19-29)77-56-51(63)50(62)52(71-15)37(9)74-56)53(64)58(67)35(7)48(60)34(6)42(79-58)24-39(28-68-12)75-47-27-57(11,66)54(38(10)73-47)78-46-26-44(70-14)49(61)36(8)72-46/h17,19-23,32,34-54,56,59-64,66-67H,16,18,24-28H2,1-15H3/b20-19+,29-17+,30-22+,31-21+,33-23+/t32-,34+,35-,36+,37+,38+,39-,40+,41-,42?,43+,44-,45?,46+,47+,48+,49-,50+,51+,52+,53-,54+,56+,57+,58-/m1/s1

InChI key

WILMROCKORZEMQ-XIQAQMKHSA-N

一般描述

Chemical structure: macrolide

生化/生理作用

Apoptolidin A is a 20-membered macrolide shown to be selectively cytotoxic against several cancer cell lines and noncytotoxic against normal cells. The molecule was originally produced by Nocardiopsis species, and its target site was identified as mitochondrial F0F1-ATPase.
Apoptolidin induces apoptosis selectively in rat glia cells transformed with the adenovirus oncogene E1A. Several minor apoptolidin congeners were isolated, known as Apoptolidins A-D. All apoptolidins were reported to inhibit growth of H292 cancer cells (lung carcinoma) in the submicromolar range. Recently, a stereo-selective synthesis of the Apoptolidin disaccharide was reported.

储存分类代码

10 - Combustible liquids

WGK

WGK 2

闪点(°F)

188.6 °F

闪点(°C)

87 °C

法规信息

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