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Merck
CN

SML0889

Sigma-Aldrich

bpV(phen)

≥95% V basis

别名:

双过氧(1,10-菲咯啉)氧钒酸钾(V)水合物

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About This Item

经验公式(希尔记法):
KVO5C12H8N2 · xH2O
CAS号:
分子量:
350.24 (anhydrous basis)
UNSPSC代码:
12352200
NACRES:
NA.77

质量水平

检测方案

≥95% V basis

形式

powder

储存条件

protect from light

颜色

faintly yellow to dark yellow

溶解性

H2O: 20 mg/mL, clear

储存温度

−20°C

SMILES字符串

O=[V]123([N]4=CC=CC5=C4C6=C(C=CC=[N]62)C=C5)(OO3)OO1.[K]

InChI

1S/C12H8N2.K.2H2O2.O.V/c1-3-9-5-6-10-4-2-8-14-12(10)11(9)13-7-1;;2*1-2;;/h1-8H;;2*1-2H;;/q;+1;;;;

InChI key

MQPXOTNOFVCXDA-UHFFFAOYSA-N

生化/生理作用

bpV(phen)是一种胰岛素受体激酶(IRK)激活剂和蛋白质磷酸酪氨酸磷酸酶抑制剂,具有对PTEN、磷酸酶和张力蛋白同源物的选择性,而后者是一种参与细胞周期调节的肿瘤抑制磷酸酶。bpV(phen)对PTEN的IC50值为38 nM,而PTPβ为343 nM、PTP-1β为920 nM。bpV(phen)在氧化应激中具有抗炎作用,包括对氧化应激诱导的心肌细胞损伤的抑制作用,可以通过ROS对PTEN的作用部分调节。它也可能参与分化。
bpV(phen)(双过氧双(二吡啶)氧钒酸钾)可通过介导NO依赖性杀微生物作用而对利什曼病的疾病进展显示出保护作用。

其他说明

光敏性

象形图

Exclamation mark

警示用语:

Warning

危险声明

危险分类

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

靶器官

Respiratory system

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable


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