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质量水平
方案
≥95% V basis
表单
powder
储存条件
protect from light
颜色
faintly yellow to dark yellow
溶解性
H2O: 20 mg/mL, clear
储存温度
−20°C
应用
已将 bpV (pic) 用于细胞培养处理，研究 HERV（人内源性逆转录病毒）转录所需的多条通路的激活途径。
生化/生理作用
bpV (pic) 含有一个极性侧链，特异性抑制 PTEN（磷酸酶和张力蛋白同源物），与其母体化合物不同，后者也靶向其他几种磷酸酶。因此，使得 bpV (pic) 成为一种更好的抑制剂。 bpV (pic) 被认为是多发性硬化症（一种自身免疫性疾病）相关的人内源性逆转录病毒的强效激活剂。
bpV (pic) 是一种蛋白磷酸酪氨酸磷酸酶的双过氧钒抑制剂，对磷酸酶和张力蛋白同源物 (PTEN) 具有选择性。
bpV (pic) 是一种蛋白磷酸酪氨酸磷酸酶的双过氧钒抑制剂，对磷酸酶和张力蛋白同源物 (PTEN) 具有选择性，PTEN 是一种参与细胞周期调控的肿瘤抑制磷酸酶。PTEN 的 bpV (pic) IC 50 值为 31 nM，相比之下，PTPβ 为 12.7 μM，PTP-1β 为61μM。bpV (pic) 也可作为胰岛素类似物和激活胰岛素受体激酶 (IRK)。
其他说明
光敏性
警示用语：
Warning
危险声明
危险分类
Eye Irrit. 2 - Skin Irrit. 2
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
历史批次信息供参考:
分析证书(COA)
Lot/Batch Number
Phosphatase and tensin homologue deleted on chromosome ten (PTEN) as a molecular target in lung epithelial wound repair.
Lai J P, et al.
British Journal of Pharmacology, 152(8), 1172-1184 (2007)
Compound signaling activates endogenous retroviruses by inducing enhancer and gene-neighborhood transcription.
Azebi S, et al.
bioRxiv, 284695 (2018)
Xiaodong Wu et al.
CNS neuroscience & therapeutics, 29(11), 3598-3611 (2023-06-13)
Neuronal abnormalities are closely associated with major depressive disorder (MDD). Available evidence suggests a role for microRNAs (miRNAs) in regulating the expression of genes involved in MDD. Hence, miRNAs that can be potential therapeutic targets need to be identified. A
Ali A Shati et al.
Clinical and experimental pharmacology & physiology, 49(2), 275-290 (2021-09-28)
This study evaluated the protective effect of resolvin D1 (RVD1) against cadmium chloride (CdCl2 )-induced hippocampal damage and memory loss in rats and investigated if such protection is mediated by modulating the PTEN/PI3K/Akt/mTOR pathway. Adult male Wistar rats (n =
Qian Chen et al.
Journal of inflammation research, 15, 2707-2720 (2022-05-04)
This study aims to investigate the cytoprotective and anti-inflammatory effects of an α2-adrenoreceptor (α2-AR) agonist, dexmedetomidine (Dex), on lipopolysaccharides (LPS)-induced acute lung injury and underlying mechanisms with focus on alveolar macrophage polarization modulation. C57BL/6 mice were intraperitoneally injected LPS (10
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