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质量水平
方案
≥95% V basis
表单
powder
储存条件
protect from light
颜色
faintly yellow to dark yellow
溶解性
H2O: 20 mg/mL, clear
储存温度
−20°C
应用
已将 bpV (pic) 用于细胞培养处理，研究 HERV（人内源性逆转录病毒）转录所需的多条通路的激活途径。
生化/生理作用
bpV (pic) 含有一个极性侧链，特异性抑制 PTEN（磷酸酶和张力蛋白同源物），与其母体化合物不同，后者也靶向其他几种磷酸酶。因此，使得 bpV (pic) 成为一种更好的抑制剂。 bpV (pic) 被认为是多发性硬化症（一种自身免疫性疾病）相关的人内源性逆转录病毒的强效激活剂。
bpV (pic) 是一种蛋白磷酸酪氨酸磷酸酶的双过氧钒抑制剂，对磷酸酶和张力蛋白同源物 (PTEN) 具有选择性，PTEN 是一种参与细胞周期调控的肿瘤抑制磷酸酶。PTEN 的 bpV (pic) IC 50 值为 31 nM，相比之下，PTPβ 为 12.7 μM，PTP-1β 为61μM。bpV (pic) 也可作为胰岛素类似物和激活胰岛素受体激酶 (IRK)。
其他说明
光敏性
警示用语：
Warning
危险声明
危险分类
Eye Irrit. 2 - Skin Irrit. 2
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
从最新的版本中选择一种：
分析证书(COA)
Lot/Batch Number
Xiaodong Wu et al.
CNS neuroscience & therapeutics, 29(11), 3598-3611 (2023-06-13)
Neuronal abnormalities are closely associated with major depressive disorder (MDD). Available evidence suggests a role for microRNAs (miRNAs) in regulating the expression of genes involved in MDD. Hence, miRNAs that can be potential therapeutic targets need to be identified. A
Phosphatase and tensin homologue deleted on chromosome ten (PTEN) as a molecular target in lung epithelial wound repair.
Lai J P, et al.
British Journal of Pharmacology, 152(8), 1172-1184 (2007)
Compound signaling activates endogenous retroviruses by inducing enhancer and gene-neighborhood transcription.
Azebi S, et al.
bioRxiv, 284695 (2018)
Ali A Shati et al.
Clinical and experimental pharmacology & physiology, 49(2), 275-290 (2021-09-28)
This study evaluated the protective effect of resolvin D1 (RVD1) against cadmium chloride (CdCl2 )-induced hippocampal damage and memory loss in rats and investigated if such protection is mediated by modulating the PTEN/PI3K/Akt/mTOR pathway. Adult male Wistar rats (n =
Reuven Falkovich et al.
Cell reports, 42(5), 112430-112430 (2023-04-26)
The complex functions of neuronal synapses depend on their tightly interconnected protein network, and their dysregulation is implicated in the pathogenesis of autism spectrum disorders and schizophrenia. However, it remains unclear how synaptic molecular networks are altered biochemically in these
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