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Merck
CN
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主要文件

安全信息

SML0882

Sigma-Aldrich

Aurora-A Inhibitor I

≥98% (HPLC)

别名:

TC‐S7010, N-(2-Chlorophenyl)-4-(2-(4-(2-(4-ethylpiperazin-1-yl)-2-oxoethyl)phenylamino)-5-fluoropyrimidin-4-ylamino)benzamide, N-(2-Chlorophenyl)-4-[[2-[[4-[2-(4-ethyl-1-piperazinyl)-2-oxoethyl]phenyl]amino]-5-fluoro-4-pyrimidinyl]amino]-benzamide

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About This Item

经验公式（希尔记法）:
C31H31ClFN7O2
CAS号:
1158838-45-9
分子量:
588.07
UNSPSC代码:
12352200
NACRES:
NA.77

质量水平

100

方案

≥98% (HPLC)

表单

powder

颜色

white to beige

溶解性

DMSO: 10 mg/mL, clear

储存温度

2-8°C

SMILES字符串

Fc1c(nc(nc1)Nc4ccc(cc4)CC(=O)N5CCN(CC5)CC)Nc2ccc(cc2)C(=O)Nc3c(cccc3)Cl

InChI

1S/C31H31ClFN7O2/c1-2-39-15-17-40(18-16-39)28(41)19-21-7-11-24(12-8-21)36-31-34-20-26(33)29(38-31)35-23-13-9-22(10-14-23)30(42)37-27-6-4-3-5-25(27)32/h3-14,20H,2,15-19H2,1H3,(H,37,42)(H2,34,35,36,38)

InChI key

AKSIZPIFQAYJGF-UHFFFAOYSA-N

应用

Aurora-A Inhibitor I has been used to study its effect on cell viability of human megakaryoblastic cell line (SET-2) and human erythroleukemia cell line (HEL) by methylthiazoletetrazolium (MTT) assay.

生化/生理作用

Aurora-A Inhibitor I is a potent inhibitor of Aurora kinase A with an IC50 of 3.4 nM and 1000-fold selectivity for Aurora A over Aurora B (better than VX-680) and even higher for CDKs. Antiproliferative IC50 values were in the vicinity of 1 μM against the human colorectal cancer cell line HCT116.
Aurora-A Inhibitor I is a potent inhibitor of Aurora kinase A.
Aurora-A Inhibitor I, also known as TC‐S7010, stimulates G2/M cell cycle arrest and apoptosis in ARID1A −/− cells.

象形图

Exclamation mark
GHS07

警示用语：

Warning

危险声明

H302

危险分类

Acute Tox. 4 Oral

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

法规信息

新产品

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
0000187897
0000187935
0000187897
0000187935
0000089748

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Synthesis and structure elucidation of polyphenols containing the N'-methyleneformohydrazide scaffold as aurora kinase inhibitors.
Dongsoo Koh et al.
Magnetic resonance in chemistry : MRC, 55(9), 864-876 (2017-05-16)
Keli Lima et al.
Scientific reports, 9(1), 9895-9895 (2019-07-11)
JAK2/STAT signaling participates in the Ph-negative myeloproliferative neoplasms (MPN) pathophysiology and has been targeted by ruxolitinib, a JAK1/2 inhibitor. In the present study, the impact of ruxolitinib treatment on cytoskeleton-related genes expression was explored. In SET2 cells, AURKA and AURKB
Sandrine Baltzer et al.
International journal of molecular sciences, 23(2) (2022-01-22)
The cAMP-dependent aquaporin-2 (AQP2) redistribution from intracellular vesicles into the plasma membrane of renal collecting duct principal cells induces water reabsorption and fine-tunes body water homeostasis. However, the mechanisms controlling the localization of AQP2 are not understood in detail. Using
Changjie Wu et al.
Nature communications, 9(1), 3212-3212 (2018-08-12)
ARID1A, a component of the SWI/SNF chromatin remodeling complex, is a tumor suppressor with a high frequency of inactivating mutations in many cancers. Therefore, ARID1A deficiency has been exploited therapeutically for treating cancer. Here we show that ARID1A has a
Shoji Hata et al.
Nature cell biology, 21(9), 1138-1151 (2019-09-05)
One of the first steps in mitotic spindle assembly is the dissolution of the centrosome linker followed by centrosome separation driven by EG5, a tetrameric plus-end-directed member of the kinesin-5 family. However, even in the absence of the centrosome linker

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