SML0874
GMQ hydrochloride
≥95% (HPLC)
别名:
2-Guanidine-4-methylquinazoline hydrochloride, 4-Methyl-2-guanidino quinazoline hydrochloride, N-(4-Methyl-2-quinazolinyl)-guanidine hydrochloride, NSC 403387 hydrochloride
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所有图片(1)
About This Item
经验公式（希尔记法）:
C10H11N5 · HCl
CAS号:
分子量:
237.69
MDL编号:
UNSPSC代码:
12352200
PubChem化学物质编号:
NACRES:
NA.77
质量水平
检测方案
≥95% (HPLC)
形式
powder
储存条件
desiccated
颜色
white to beige
溶解性
DMSO: 2 mg/mL, clear (warmed)
储存温度
room temp
SMILES字符串
CC1=NC(NC(N)=N)=NC2=C1C=CC=C2.Cl
InChI
1S/C10H11N5.ClH/c1-6-7-4-2-3-5-8(7)14-10(13-6)15-9(11)12;/h2-5H,1H3,(H4,11,12,13,14,15);1H
InChI key
VNPZWQRWOHFAPD-UHFFFAOYSA-N
生化/生理作用
GMQ/2-Guanidine-4-methylquinazoline is a potent and selective modulator of acid-sensing ion channel (ASIC) that activates ASIC3 channels under neutral pH. GQM blocks acid-induced maximal peak current and alters ASICs pH dependence for activation and inactivation.
警示用语：
Warning
危险声明
危险分类
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
靶器官
Respiratory system
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
Kojun Tsuji et al.
American journal of physiology. Gastrointestinal and liver physiology, 319(5), G564-G572 (2020-09-04)
Capsaicin powerfully evokes the swallowing reflex and is a known therapeutic agent for improving dysphagia and preventing aspiration pneumonia. However, the role of capsaicin-sensitive nerves in the initiation of swallowing evoked by various natural stimuli remains unclear. To explore this
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