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Merck
CN
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文件

SML0873

Sigma-Aldrich

Y16

≥98% (HPLC)

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别名:
4-[[3-[(3-Methylphenyl)methoxy]phenyl]methylene]-1-phenyl-3,5-pyrazolidinedione
经验公式（希尔记法）:
C24H20N2O3
CAS号:
429653-73-6
分子量:
384.43
UNSPSC代码:
12352200
NACRES:
NA.77

质量水平

100

检测方案

≥98% (HPLC)

形式

powder

颜色

, faint yellow to dark orange

溶解性

DMSO: 5 mg/mL, clear (warmed)

储存温度

2-8°C

生化/生理作用

Y16 blocks the binding of LARG, a DBL-family Rho guanine nucleotide exchange factor, with Rho (Kd = 80 nM). Y16 specifically inhibits LARG catalyzed activation of RhoA and RhoA signaling pathways. Y16 blocks the growth and migration of MCF7 breast cancer cells.

特点和优势

This compound is a featured product for Cyclic Nucleotide research. Click here to discover more featured Cyclic Nucleotide products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
This compound is featured on the GTP Binding Proteins (Low Molecular Weight) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

其他说明

Product is a racemic mixture of E/Z isomers.

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

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Bo Zhang et al.
Cells, 9(3) (2020-03-08)
Rho GTPases, including Rho, Cdc42, Rac and ROP subfamilies, are key signaling molecules in RNA polymerase II (Pol II) transcriptional control. Our prior work has shown that plant ROP and yeast Cdc42 GTPases similarly modulate Ser2 and Ser5 phosphorylation status
Sreeharsha Gurrapu et al.
Cell death and differentiation, 25(7), 1259-1275 (2018-03-21)
Semaphorin 4C (Sema4C) expression in human breast cancers correlates with poor disease outcome. Surprisingly, upon knock-down of Sema4C or its receptor PlexinB2 in diverse mammary carcinoma cells (but not their normal counterparts), we observed dramatic growth inhibition associated with impairment

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