SML0868
嘌吗啡胺
≥98% (HPLC), powder, Hedgehog signaling activator
别名:
2-（1-萘基）-6-（4-吗啉苯胺）-9-环己嘌呤; 9-环己基-N- [4-（4-吗啉基）苯基]-2-（1-萘氧基）-
产品名称
嘌吗啡胺, ≥98% (HPLC)
solubility
DMSO: 5 mg/mL, clear (warmed)
SMILES string
N7(CCOCC7)c1ccc(cc1)Nc2nc(nc5[n](cnc52)C6CCCCC6)Oc3c4c(ccc3)cccc4
InChI
1S/C31H32N6O2/c1-2-9-25(10-3-1)37-21-32-28-29(33-23-13-15-24(16-14-23)36-17-19-38-20-18-36)34-31(35-30(28)37)39-27-12-6-8-22-7-4-5-11-26(22)27/h4-8,11-16,21,25H,1-3,9-10,17-20H2,(H,33,34,35)
InChI key
FYBHCRQFSFYWPY-UHFFFAOYSA-N
assay
≥98% (HPLC)
form
powder
color
white to beige
storage temp.
−20°C
Quality Level
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相关类别
Application
Purmorphamine已被用于研究Tupfel长鳍株斑马鱼中Hedgehog信号通路上调的影响。
Biochem/physiol Actions
Purmorphamine可直接结合Smoothened（Smo）受体，激活Hedgehog（Hh）信号通路。
Purmorphamine可直接结合Smoothened（Smo）受体，激活Hedgehog（Hh）信号通路。多项研究已经显示，Purmorphamine可诱导成骨细胞的分化、从人胚胎干细胞中产生心肌细胞、增加人纹状体神经干细胞系的神经元分化、以及将人脐带间充质干细胞（hUCMSC）分化成运动神经元。
signalword
Warning
hcodes
Hazard Classifications
Muta. 2
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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Biosensors on the membrane of the vascular endothelium are responsible for sensing mechanical and chemical signals in the blood. Transduction of these stimuli into intracellular signaling cascades regulate cellular processes including ion transport, gene expression, cell proliferation, and/or cell death.
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