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主要文件

COO原产地证书/COA分析证书

安全信息

安全和法规

SML0864

EMPA

Name: EMPA
Brand: SIGMA

≥98% (HPLC)

别名:

N-Ethyl-2-[(6-methoxy-3-pyridinyl)[(2-methylphenyl)sulfonyl]amino]-N-(3-pyridinylmethyl)-acetamide

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About This Item

经验公式（希尔记法）:

C₂₃H₂₆N₄O₄S

CAS号:

680590-49-2

分子量:

454.54

UNSPSC代码:

51111800

NACRES:

NA.77

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Sigma-Aldrich

SML2804

达格列净

Sigma-Aldrich

721174

2-(三丁基锡基甲醇)嘧啶

Sigma-Aldrich

A65603

4-(氨基甲基)吡啶

Sigma-Aldrich

227056

N,N-二甲基甲酰胺

S940429

3,4,5-TRIBROMO-1H-PYRAZOLE

Sigma-Aldrich

SML2758

达格列净丙二醇一水合物

Sigma-Aldrich

178470

4-(三氟甲基)苯酚

T158747

[4-[4-(4-ACETYL-3-HYDROXY-2-PROPYLPHENOXY)BUTOXY]-3-CHLOROPHENYL]ACETIC ACID

Supelco

65363

(R)-α-甲氧基-α-（三氟甲基）苯乙酰氯

USP

1163253

达格列净丙二醇一水合物

质量水平

100

方案

≥98% (HPLC)

表单

film

颜色

white to light brown

储存温度

−20°C

SMILES字符串

[S](=O)(=O)(N(CC(=O)N(CC)Cc3cnccc3)c2cnc(cc2)OC)c1c(cccc1)C

InChI

1S/C23H26N4O4S/c1-4-26(16-19-9-7-13-24-14-19)23(28)17-27(20-11-12-22(31-3)25-15-20)32(29,30)21-10-6-5-8-18(21)2/h5-15H,4,16-17H2,1-3H3

InChI key

KJPHTXTWFHVJIG-UHFFFAOYSA-N

生化/生理作用

EMPA is a potent, selective OX2R antagonist (IC₅₀ = 2.3 nM). EMPA binds reversibly to OX2R and inhibits orexin-a and -b-evoked intracellular calcium flux in cells expressing recombinant OX2R, but not OX1R.

EMPA is a potent, selective OX2R antagonist.

外形

This product is solubilized for packaging and then dried down for shipment. It would appear as a lyophilized powder or film on the vial. Solvent should be added directly to the vial to prepare their sample for testing.