SML0860
阿比朵尔 盐酸盐
≥98% (HPLC)
别名:
6-溴-4-((二甲氨基)甲基)-5-羟基-1-甲基-2-((苯硫基)甲基)-1H-吲哚-3-羧酸乙酯 单盐酸盐
SMILES string
S(Cc2[n](c3c(c(c(c(c3)Br)O)CN(C)C)c2C(=O)OCC)C)c1ccccc1.[Cl-].O.[H+]
InChI
1S/C22H25BrN2O3S.ClH.H2O/c1-5-28-22(27)20-18(13-29-14-9-7-6-8-10-14)25(4)17-11-16(23)21(26)15(19(17)20)12-24(2)3;;/h6-11,26H,5,12-13H2,1-4H3;1H;1H2
InChI key
PLWQHPWNKPKQJT-UHFFFAOYSA-N
assay
≥98% (HPLC)
form
powder
storage condition
desiccated
color
white to beige
solubility
DMSO: 20 mg/mL, clear
storage temp.
−20°C
Quality Level
Biochem/physiol Actions
盐酸阿比多尔（ARB）是一种小分子单眼用化合物。用于预防流感病毒（IFV）诱导的重症肺炎和病毒相关细胞因子失调。ARB还具有一些免疫调节特性，包括干扰素诱导和巨噬细胞活化的作用。
阿比多尔是一种广谱抗病毒药，已证明对多种包膜和非包膜病毒具有活性，并在临床上用于治疗流感。阿比多尔抑制病毒进入宿主细胞并刺激免疫反应。阿比多尔抑制病毒衣壳与靶细胞的细胞膜之间的融合，从而防止病毒进入。
阿比多尔是一种抗流感抗病毒药。
signalword
Warning
hcodes
Hazard Classifications
Eye Irrit. 2 - Skin Irrit. 2
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Qiang Zhang et al.
Yao xue xue bao = Acta pharmaceutica Sinica, 45(3), 289-299 (2011-03-01)
Influenza is a major threat to millions of people worldwide. Vaccines and antiviral agents are two main options available to reduce the impact of the influenza virus, while anti-influenza agents are the most effective means to prevent the transmission of
S Ia Loginova et al.
Antibiotiki i khimioterapiia = Antibiotics and chemoterapy [sic], 55(1-2), 6-11 (2010-06-30)
Efficacy of arbidol and ridostin in cupping postvaccinal complications due to variolation was studied by the clinico-virological, hematological and biochemical indices and it was shown that arbidol was efficient in cupping development of dermal complications, lowered the severity of the
Xin Xiong et al.
Journal of AOAC International, 94(4), 1100-1105 (2011-09-17)
An HPLC/MS/MS method for the determination of arbidol in human plasma was developed. Arbidol and internal standard (loratadine) were extracted from alkaline plasma with tert-butyl methyl ether and analyzed on a Zorbax SB C18 column (30 x 2.1 mm id
Elodie Teissier et al.
PloS one, 6(1), e15874-e15874 (2011-02-02)
The broad-spectrum antiviral arbidol (Arb) inhibits cell entry of enveloped viruses by blocking viral fusion with host cell membrane. To better understand Arb mechanism of action, we investigated its interactions with phospholipids and membrane peptides. We demonstrate that Arb associates
Meng Wang et al.
Drug and chemical toxicology, 33(3), 244-253 (2010-05-01)
The antiviral drug combination consisting of arbidol and acetaminophen was investigated for its 4-week repeated oral administration in Sprague-Dawley rats. Groups of rats (10/sex in low-dose group, 15/sex in other three groups) were given at doses of 0, 200, 400
商品
Bioactive small molecules for immune system signaling target identification/validation and antibiotics, antivirals, and antifungals offered.
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