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Merck
CN
所有图片(3)

文件

SML0843

Sigma-Aldrich

ISRIB

≥98% (HPLC)

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所有图片(3)
别名:
反式-N,N′-1,4-环己烷二基双 \ [2-（4-氯苯氧基）-乙酰胺, 反式-N,N′-（环己烷-1,4-二基）双（2-（4-氯苯氧基）乙酰胺, 整合应激反应抑制剂
经验公式（希尔记法）:
C22H24Cl2N2O4
CAS号:
1597403-47-8
分子量:
451.34
UNSPSC代码:
12352200
PubChem化学物质编号:
329825607
NACRES:
NA.77

质量水平

100

检测方案

≥98% (HPLC)

形式

powder

颜色

white to beige

溶解性

DMSO: 1 mg/mL, clear (warmed)

储存温度

2-8°C

SMILES字符串

ClC1=CC=C(OCC(N[C@@H]2CC[C@@H](NC(COC3=CC=C(Cl)C=C3)=O)CC2)=O)C=C1

InChI

1S/C22H24Cl2N2O4/c23-15-1-9-19(10-2-15)29-13-21(27)25-17-5-7-18(8-6-17)26-22(28)14-30-20-11-3-16(24)4-12-20/h1-4,9-12,17-18H,5-8,13-14H2,(H,25,27)(H,26,28)/t17-,18-

InChI key

HJGMCDHQPXTGAV-IYARVYRRSA-N

应用

ISRIB（综合应激反应抑制剂）已被用作综合应激反应的抑制剂。

生化/生理作用

ISRIB 是一种血脑屏障渗透剂，是内质网应激适应性受损的有效选择性综合应激反应 (ISR) 抑制剂。ISRIB 是 PERK 信号的有效抑制剂，可有效逆转 eIF2a 磷酸化作用，恢复细胞翻译能力。ISRIB 增强啮齿类动物的认知记忆。
ISRIB（综合应激反应抑制剂）作为一种药物，赋予细胞抵抗真核起始因子2（eIF2）α磷酸化（如激活转录因子4（ATF4）和真核翻译起始因子4E（eIF4E）结合）的下游作用的抗性 蛋白质1（4E-BP1）诱导。

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

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