跳转至内容
Merck
CN
所有图片(3)

主要文件

查看所有文档

SML0843

Sigma-Aldrich

ISRIB

≥98% (HPLC), powder, integrated stress response inhibitor

别名:

反式-N,N′-1,4-环己烷二基双 \ [2-（4-氯苯氧基）-乙酰胺, 反式-N,N′-（环己烷-1,4-二基）双（2-（4-氯苯氧基）乙酰胺, 整合应激反应抑制剂

登录查看公司和协议定价
所有图片(3)

About This Item

经验公式（希尔记法）:
C22H24Cl2N2O4
CAS号:
1597403-47-8
分子量:
451.34
UNSPSC代码:
12352200
PubChem化学物质编号:
329825607
NACRES:
NA.77

产品名称

ISRIB, ≥98% (HPLC)

质量水平

100

方案

≥98% (HPLC)

表单

powder

颜色

white to beige

溶解性

DMSO: 1 mg/mL, clear (warmed)

储存温度

2-8°C

SMILES字符串

ClC1=CC=C(OCC(N[C@@H]2CC[C@@H](NC(COC3=CC=C(Cl)C=C3)=O)CC2)=O)C=C1

InChI

1S/C22H24Cl2N2O4/c23-15-1-9-19(10-2-15)29-13-21(27)25-17-5-7-18(8-6-17)26-22(28)14-30-20-11-3-16(24)4-12-20/h1-4,9-12,17-18H,5-8,13-14H2,(H,25,27)(H,26,28)/t17-,18-

InChI key

HJGMCDHQPXTGAV-IYARVYRRSA-N

应用

ISRIB（综合应激反应抑制剂）已被用作综合应激反应的抑制剂。

生化/生理作用

ISRIB 是一种血脑屏障渗透剂，是内质网应激适应性受损的有效选择性综合应激反应 (ISR) 抑制剂。ISRIB 是 PERK 信号的有效抑制剂，可有效逆转 eIF2a 磷酸化作用，恢复细胞翻译能力。ISRIB 增强啮齿类动物的认知记忆。
ISRIB（综合应激反应抑制剂）作为一种药物，赋予细胞抵抗真核起始因子2（eIF2）α磷酸化（如激活转录因子4（ATF4）和真核翻译起始因子4E（eIF4E）结合）的下游作用的抗性 蛋白质1（4E-BP1）诱导。

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

从最新的版本中选择一种：

分析证书(COA)

Lot/Batch Number
0000236877
0000189198
0000236877
0000189198
0000178621

没有发现合适的版本？

如果您需要特殊版本，可通过批号或批次号查找具体证书。

搜索COA

已有该产品？

在文件库中查找您最近购买产品的文档。

访问文档库

B Balakrishnan et al.
Biochimica et biophysica acta. Molecular basis of disease, 1865(11), 165516-165516 (2019-07-31)
Loss of galactose-1 phosphate uridylyltransferase (GALT) activity in humans results in Classic Galactosemia, and the GalT-deficient (GalT-/-) mouse mimics the patient condition. GalT-/- ovaries display elevated endoplasmic reticulum (ER) stress marker, BiP, and downregulated canonical phosphatidylinositol 3-kinase (Pi3k)/protein kinase B
Z D Kabir et al.
Molecular psychiatry, 22(8), 1096-1109 (2017-06-07)
CACNA1C, encoding the Ca
Caitlin M Rodriguez et al.
Nature neuroscience, 23(3), 386-397 (2020-02-19)
Repeat-associated non-AUG-initiated translation of expanded CGG repeats (CGG RAN) from the FMR1 5'-leader produces toxic proteins that contribute to neurodegeneration in fragile X-associated tremor/ataxia syndrome. Here we describe how unexpanded CGG repeats and their translation play conserved roles in regulating
Philippe Fernandes et al.
Communications biology, 4(1), 127-127 (2021-01-31)
Common fragile sites (CFSs) are genomic regions frequently involved in cancer-associated rearrangements. Most CFSs lie within large genes, and their instability involves transcription- and replication-dependent mechanisms. Here, we uncover a role for the mitochondrial stress response pathway in the regulation
Ye-Jin Park et al.
International journal of molecular sciences, 21(15) (2020-08-01)
Stress granules are membraneless organelles composed of numerous components including ribonucleoproteins. The stress granules are characterized by a dynamic complex assembly in response to various environmental stressors, which has been implicated in the coordinated regulation of diverse biological pathways, to
查看所有相关文献

我们的科学家团队拥有各种研究领域经验，包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.

联系技术服务部门