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主要文件

COO原产地证书/COA分析证书

安全信息

安全和法规

SML0827

FPH1

Name: FPH1
Brand: SIGMA

≥98% (HPLC)

别名:

2-(N-(5-Chloro-2-methylphenyl)(methylsulfonamido)-N-(2,6-difluorophenyl)-acetamide, 2-[(5-Chloro-2-methylphenyl)(methylsulfonyl)amino]-N-(2,6-difluorophenyl)-acetamide, BRD-6125

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About This Item

经验公式（希尔记法）:

C₁₆H₁₅ClF₂N₂O₃S

CAS号:

708219-39-0

分子量:

388.82

UNSPSC代码:

12352200

NACRES:

NA.77

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D131

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Supelco

PHR3306

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Sigma-Aldrich

D5942

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M8046

米非司酮

质量水平

100

方案

≥98% (HPLC)

表单

powder

颜色

white to beige

溶解性

DMSO: 20 mg/mL, clear

储存温度

−20°C

SMILES字符串

Fc1c(c(ccc1)F)NC(=O)CN([S](=O)(=O)C)c2c(ccc(c2)Cl)C

InChI

1S/C16H15ClF2N2O3S/c1-10-6-7-11(17)8-14(10)21(25(2,23)24)9-15(22)20-16-12(18)4-3-5-13(16)19/h3-8H,9H2,1-2H3,(H,20,22)

InChI key

WAOBCCBUTHNTFO-UHFFFAOYSA-N

生化/生理作用

FPH1 (BRD-6125) induces functional proliferation of primary human hepatocytes in vitro.

FPH1 (BRD-6125) induces functional proliferation of primary human hepatocytes in vitro. Human induced pluripotent stem (iPS) cells can be differentiated toward hepatocyte-like (iHep) cells, but replication is not great, and cells typically show an immature hepatic phenotype and have limited use as a renewable source of functional human hepatocytes. FPH1 induced hepatocyte colonies were used in conjunction with FH1 (BRD-K4477) to induce a more mature phenotype. Cultures treated with both FH1 and FPH1 contained larger colonies of hepatocyte-like (iHep) cells, which showed more pronounced hepatocyte morphologies with a more mature phenotype than previously obtainable.