SML0826

FH1

Name: FH1
Brand: SIGMA

≥98% (HPLC)

别名:

BRD-K4477, N,N′-(Methylenedi-4,1-phenylene)bis-acetamide, N,N′-(Methylenedi-4,1-phenylene)diacetamide, NSC 12407

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关于此项目

经验公式（希尔记法）:

C₁₇H₁₈N₂O₂

化学文摘社编号:

2719-05-3

分子量:

282.34

UNSPSC Code:

12352200

NACRES:

NA.77

Assay:

≥98% (HPLC)

Form:

powder

Quality level:

100

主要文件

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SMILES string

N(c1ccc(cc1)Cc2ccc(cc2)NC(=O)C)C(=O)C

InChI

1S/C17H18N2O2/c1-12(20)18-16-7-3-14(4-8-16)11-15-5-9-17(10-6-15)19-13(2)21/h3-10H,11H2,1-2H3,(H,18,20)(H,19,21)

InChI key

OEXMNSOPAKOPEF-UHFFFAOYSA-N

assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 10 mg/mL, clear (warmed)

storage temp.

2-8°C

Quality Level

100

Biochem/physiol Actions

FH1 (BRD-K4477) was found to enhance hepatocyte functions and promote the differentiation of induced pluripotent stem cell–derived hepatocytes toward a more mature phenotype than what had previouslybeen obtainable. Human induced pluripotent stem (iPS) cells that are differentiated toward hepatocyte-like (iHep) cells typically show an immature hepatic phenotype and have limited use as a renewable source of functional human hepatocytes. Cultures treated with both FH1 (BRD-K4477) and another compound that induces proliferation, FPH1 (BRD-6125), contained larger colonies of iHep cells, which showed more pronounced hepatocyte morphologies with a more mature phenotype than previously obtainable.

FH1 (BRD-K4477) was found to enhance hepatocyte functions and promote the differentiation of induced pluripotent stem cell–derived hepatocytes toward a more mature phenotype.