所有图片(1)

主要文件

COO原产地证书/COA分析证书

SML0809

LE 135

Name: LE 135
Brand: SIGMA

≥98% (HPLC)

别名:

4-(7,8,9,10-Tetrahydro-5,7,7,10,10-pentamethyl-5H-benzo[e]naphtho[2,3-b][1,4]diazepin-13-yl)-benzoic acid, LE-135

登录查看公司和协议定价

所有图片(1)

About This Item

经验公式（希尔记法）:

C₂₉H₃₀N₂O₂

CAS号:

155877-83-1

分子量:

438.56

UNSPSC代码:

12352200

NACRES:

NA.77

推荐产品

Slide 1 of 10

1 of 10

Sigma-Aldrich

SML1465

UNC0379 trifluoroacetate salt

Sigma-Aldrich

SML2183

LY2955303

Sigma-Aldrich

SML2015

MM11253

Sigma-Aldrich

SML1084

BMS-195614

Sigma-Aldrich

SML0573

Ro 41-5253

Sigma-Aldrich

SML2034

AGN 193109

Sigma-Aldrich

A8843

AM580

Sigma-Aldrich

SML2665

AGN194310

Sigma-Aldrich

T3757

TTNPB

Sigma-Aldrich

SML2498

Vatalanib dihydrochloride

质量水平

100

方案

≥98% (HPLC)

表单

powder

颜色

yellow to orange

溶解性

DMSO: 15 mg/mL, clear

储存温度

2-8°C

SMILES字符串

N1(c2c(cc5c(c2)C(CCC5(C)C)(C)C)N=C(c4c1cccc4)c3ccc(cc3)C(=O)O)C

InChI

1S/C29H30N2O2/c1-28(2)14-15-29(3,4)22-17-25-23(16-21(22)28)30-26(18-10-12-19(13-11-18)27(32)33)20-8-6-7-9-24(20)31(25)5/h6-13,16-17H,14-15H2,1-5H3,(H,32,33)

InChI key

YZZAIQOVMHVWBS-UHFFFAOYSA-N

应用

LE 135 has been used for in vitro islet treatment.

生化/生理作用

LE135 is a retinoic acid receptor (RAR) antagonist with selectivity for RARβ (Ki = 220 nM) over RARα (Ki = 1.4 μM).

LE135 is a retinoic acid receptor (RAR) antagonist with selectivity for RARβ (Ki = 220 nM) over RARα (Ki = 1.4 μM). LE135 inhibits retinoic acid-induced transcriptional activation of RARβ (>70% inhibition at 10 μM), but not RARα, RARγ or retinoid X receptor α (RXRα). There is high interest in retinoic acid receptors for cancer and for differentiation studies. LE135 has been shown to inhibit retinoid Am80-induced differentiation of human promyelocytic leukemia HL-60 cells with an IC₅₀ value of 0.2 μM. LE135 has been used to study the role of a retinoic acid receptor-β (RARβ) on the differentiation of mesenchymal stem cells, and was found to inhibit the neuronal differentiation promoting effects of all-trans retinoic acid (ATRA) on mesenchymal stem cells.

特点和优势

This compound is featured on the Nuclear Receptors (Non-Steroids) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.