SML0797
氟班色林
≥98% (HPLC)
别名:
1,3-二氢-1-[2-[4-[3-(三氟甲基)苯基]-1-哌嗪基]乙基]-2H-苯并咪唑-2-酮, BIMT 17, BIMT 17BS
SMILES string
FC(F)(F)c1ccc(cc1)N2CCN(CC2)CC[n]3c4c([nH][c]3=O)cccc4
InChI
1S/C20H21F3N4O/c21-20(22,23)15-5-7-16(8-6-15)26-12-9-25(10-13-26)11-14-27-18-4-2-1-3-17(18)24-19(27)28/h1-8H,9-14H2,(H,24,28)
InChI key
CCIZQGRSEAHATK-UHFFFAOYSA-N
assay
≥98% (HPLC)
form
powder
color
white to beige
solubility
DMSO: 10 mg/mL, clear
storage temp.
2-8°C
Quality Level
Biochem/physiol Actions
氟班色林是 5-HT1A 受体激动剂和 5-HT2A 受体拮抗剂。
氟班色林是 5-HT1A 受体激动剂和 5-HT2A 受体拮抗剂。氟班色林对人 5-HT1A受体 (Ki = 1 nm) 具有高亲和力，对 5-HT2A (Ki = 49 nm) 和 D4 (Ki = 4–24 nm) 受体亲和力较低，对多种其他神经递质受体和离子通道的亲和力可忽略不计。氟班色林被用作女性绝经前性欲减退 (HSDD) 的一种新型非激素治疗方法。氟班色林。最近，在帕金森氏病模型中发现氟班色林可减轻 L-DOPA 引起的运动障碍。
Features and Benefits
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signalword
Danger
hcodes
Hazard Classifications
Acute Tox. 3 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
target_organs
Respiratory system
存储类别
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
新产品
此项目有
John Thorp et al.
The journal of sexual medicine, 9(3), 793-804 (2012-01-14)
Hypoactive Sexual Desire Disorder (HSDD) is characterized by low sexual desire that causes marked distress or interpersonal difficulty. To assess the efficacy and tolerability of flibanserin, a postsynaptic 5-HT1A agonist/5-HT2A antagonist, in the treatment of premenopausal women with HSDD. North
Dysfunctional women remain unsexed.
Michael G Wyllie
BJU international, 106(3), 431-432 (2010-07-27)
Drug for low sexual desire carries significant harms, FDA advisers find.
Ray Moynihan
BMJ (Clinical research ed.), 341, c3339-c3339 (2010-07-09)
Leonard R Derogatis et al.
The journal of sexual medicine, 9(4), 1074-1085 (2012-01-18)
Hypoactive sexual desire disorder (HSDD) is the most common form of female sexual dysfunction and is characterized by low sexual desire that causes distress. The aim of this study was to assess the efficacy and safety of flibanserin, a postsynaptic
Sidney Kennedy
The journal of sexual medicine, 7(10), 3449-3459 (2010-07-22)
Flibanserin, a novel 5-HT(1A) agonist and 5-HT(2A) antagonist, has the potential to treat sexual dysfunction. Provide historical perspective on the rationale for development of flibanserin to treat sexual dysfunction, based on post hoc analyses of data. The Arizona Sexual Experiences
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