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Merck
CN

SML0784

Sigma-Aldrich

BMS-303141

≥98% (HPLC)

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别名:
3,5-二氯-2-羟基-N-(4-甲氧基[1,1'-联苯]-3-基)苯磺酰胺
经验公式(希尔记法):
C19H15Cl2NO4S
分子量:
424.30
MDL编号:
UNSPSC代码:
12352200
NACRES:
NA.77

质量水平

检测方案

≥98% (HPLC)

形式

powder

颜色

white to beige

溶解性

DMSO: 20 mg/mL, clear

储存温度

2-8°C

SMILES字符串

O=S(NC1=C(OC)C=CC(C2=CC=CC=C2)=C1)(C3=C(O)C(Cl)=CC(Cl)=C3)=O

InChI

1S/C19H15Cl2NO4S/c1-26-17-8-7-13(12-5-3-2-4-6-12)9-16(17)22-27(24,25)18-11-14(20)10-15(21)19(18)23/h2-11,22-23H,1H3

InChI key

SIIPNDKXZOTLEA-UHFFFAOYSA-N

相关类别

应用

BMS-303141已被用于抑制乳腺癌细胞系中的ATP柠檬酸裂合酶。

生化/生理作用

BMS-303141是ATP柠檬酸裂解酶(ACL)的一种有效抑制剂。 BMS-303141可抑制HepG2细胞中的脂质合成,IC50值为8μM。同时,在鼠高脂血症模型中,其可降低血浆中的甘油三酸酯的含量。

危险声明

预防措施声明

危险分类

Aquatic Chronic 4

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable


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