SML0784
BMS-303141
≥98% (HPLC), ATP citrate lyase inhibitor, powder
别名:
3,5-二氯-2-羟基-N-(4-甲氧基[1,1′-联苯]-3-基)苯磺酰胺
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关于此项目
经验公式（希尔记法）:
C19H15Cl2NO4S
化学文摘社编号:
分子量:
424.30
NACRES:
NA.77
UNSPSC Code:
51111800
MDL number:
产品名称
BMS-303141, ≥98% (HPLC)
InChI key
SIIPNDKXZOTLEA-UHFFFAOYSA-N
SMILES string
O=S(NC1=C(OC)C=CC(C2=CC=CC=C2)=C1)(C3=C(O)C(Cl)=CC(Cl)=C3)=O
InChI
1S/C19H15Cl2NO4S/c1-26-17-8-7-13(12-5-3-2-4-6-12)9-16(17)22-27(24,25)18-11-14(20)10-15(21)19(18)23/h2-11,22-23H,1H3
assay
≥98% (HPLC)
form
powder
color
white to beige
solubility
DMSO: 20 mg/mL, clear
storage temp.
2-8°C
Quality Level
相关类别
Application
BMS-303141已被用于抑制乳腺癌细胞系中的ATP柠檬酸裂合酶。
Biochem/physiol Actions
BMS-303141是ATP柠檬酸裂解酶（ACL）的一种有效抑制剂。
BMS-303141是ATP柠檬酸裂解酶（ACL）的一种有效抑制剂。 BMS-303141可抑制HepG2细胞中的脂质合成，IC50值为8μM。同时，在鼠高脂血症模型中，其可降低血浆中的甘油三酸酯的含量。
hcodes
pcodes
Hazard Classifications
Aquatic Chronic 4
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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