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Merck
CN
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文件

安全信息

SML0781

Sigma-Aldrich

NSC109555

≥98% (HPLC)

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别名:
2,2′-[Carbonylbis(imino-4,1-phenyleneethylidyne)]-bis-Hydrazinecarboximidamide methanesulfonate (1:2)
经验公式（希尔记法）:
C19H24N10O · 2CH3SO3H
CAS号:
15427-93-7
分子量:
600.67
UNSPSC代码:
12352200
NACRES:
NA.77

检测方案

≥98% (HPLC)

形式

powder

颜色

white to beige

溶解性

H2O: 5 mg/mL, clear (warmed)

储存温度

2-8°C

InChI

1S/C19H24N10O.2CH4O3S/c1-11(26-28-17(20)21)13-3-7-15(8-4-13)24-19(30)25-16-9-5-14(6-10-16)12(2)27-29-18(22)23;2*1-5(2,3)4/h3-10H,1-2H3,(H4,20,21,28)(H4,22,23,29)(H2,24,25,30);2*1H3,(H,2,3,4)/b26-11+,27-12+;;

InChI key

HXDBGZUARNKHBV-XMDRLFCYSA-N

生化/生理作用

NSC109555 is a selective inhibitor of Chk2 (IC50 = 310 nM). The compound is reversible and competitive for ATP, and displays little or no activity against other related kinases, including Chk1, at concentrations up to 10 μM.

特点和优势

This compound is featured on the Csk page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

法规信息

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Tirosh Shapira et al.
Frontiers in microbiology, 11, 553962-553962 (2020-10-13)
A screen of a eukaryotic kinase inhibitor library in an established intracellular infection model identified a set of drug candidates enabling intracellular killing of Mycobacterium tuberculosis (M.tb). Screen validity was confirmed internally by a Z' = 0.5 and externally by

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c-Src kinase (Csk)

The C-terminal c-Src kinase (Csk) is a 50-kDa cytosolic tyrosine kinase expressed in all examined cell types

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