所有图片(1)
About This Item
经验公式（希尔记法）:
C12H5O8
CAS号:
分子量:
277.16
MDL编号:
UNSPSC代码:
12352200
PubChem化学物质编号:
NACRES:
NA.77
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质量水平
方案
≥95% (HPLC)
表单
powder
储存条件
desiccated
颜色
light yellow to light brown
溶解性
DMSO: 5 mg/mL, clear
储存温度
−20°C
SMILES字符串
OC1=C(O)C(O)=CC2=C1C3=C(C=C(O)C(O3)=O)OC2=O
InChI
1S/C12H6O8/c13-4-1-3-7(9(16)8(4)15)10-6(19-11(3)17)2-5(14)12(18)20-10/h1-2,13-16H
InChI key
VYKVZHXHVUVABA-UHFFFAOYSA-N
生化/生理作用
棓黄素是乳酸脱氢酶（LDH）的抑制剂。该化合物阻断（LDH-A 和 -B）的两种同种型，Ki 值分别为 5.5 和 15 μM。通过棓黄素抑制糖酵解途径可诱导乳腺肿瘤细胞系发生氧化应激和细胞凋亡。
警示用语：
Warning
危险声明
危险分类
Acute Tox. 4 Oral
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
从最新的版本中选择一种：
分析证书(COA)
Lot/Batch Number
Simone Kumstel et al.
Scientific reports, 10(1), 16931-16931 (2020-10-11)
Severity assessment of animal experiments is mainly conducted by using subjective parameters. A widely applicable biomarker to assess animal distress could contribute to an objective severity assessment in different animal models. Here, the distress of three murine animal models for
John A G Moir et al.
Pancreas, 49(10), 1364-1371 (2020-10-31)
Pancreatic stellate cells (PSCs) play a key metabolic role within the tumor microenvironment (stroma) of pancreatic ductal adenocarcinoma (PDAC), being glycolytic and associated with protumorigenic acidification from excess lactate. This study investigates the clinical significance of glycolytic enzyme lactate dehydrogenase
Abd El-Galil E Amr et al.
Molecules (Basel, Switzerland), 25(5) (2020-03-04)
A series of branched tetrapeptide Schiff bases 3-6 were designed and synthesized from corresponding tetrapeptide hydrazide 2 as a starting material.In vitroevaluation of the synthesized compounds 4-6 against breast MCF-7 carcinoma cells identified their excellent anticancer potency, with IC50 ranging
Guorong Cheng et al.
Talanta, 209, 120554-120554 (2020-01-02)
Lactate dehydrogenase (LDH), catalyzing the conversion of pyruvate to lactate during glycolysis, is overexpressed in cancer cells. LDH inhibitors are a promising approach for the treatment of cancer. But up till now, there is limited method for rapid screening of
Jilong Zhou et al.
Biology of reproduction, 99(2), 308-318 (2018-03-17)
Autophagy is an essential cellular mechanism that degrades cytoplasmic proteins and organelles to recycle their components. Here we showed that autophagy was essential for the glycolysis switch and energy homeostasis in mouse granulosa cells under hypoxic condition. Our data indicated
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