SML0776
棓黄素
≥95% (HPLC)
别名:
3,8,9,10-四羟基吡喃并[3,2-C] [2]苯并吡喃-2,6-二酮, NSC 107022
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关于此项目
经验公式（希尔记法）:
C12H5O8
化学文摘社编号:
分子量:
277.16
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
MDL number:
InChI
1S/C12H6O8/c13-4-1-3-7(9(16)8(4)15)10-6(19-11(3)17)2-5(14)12(18)20-10/h1-2,13-16H
SMILES string
OC1=C(O)C(O)=CC2=C1C3=C(C=C(O)C(O3)=O)OC2=O
InChI key
VYKVZHXHVUVABA-UHFFFAOYSA-N
assay
≥95% (HPLC)
form
powder
storage condition
desiccated
color
light yellow to light brown
solubility
DMSO: 5 mg/mL, clear
storage temp.
−20°C
Quality Level
Biochem/physiol Actions
棓黄素是乳酸脱氢酶（LDH）的抑制剂。
棓黄素是乳酸脱氢酶（LDH）的抑制剂。该化合物阻断（LDH-A 和 -B）的两种同种型，Ki 值分别为 5.5 和 15 μM。通过棓黄素抑制糖酵解途径可诱导乳腺肿瘤细胞系发生氧化应激和细胞凋亡。
signalword
Warning
hcodes
Hazard Classifications
Acute Tox. 4 Oral
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Simone Kumstel et al.
Scientific reports, 10(1), 16931-16931 (2020-10-11)
Severity assessment of animal experiments is mainly conducted by using subjective parameters. A widely applicable biomarker to assess animal distress could contribute to an objective severity assessment in different animal models. Here, the distress of three murine animal models for
Abd El-Galil E Amr et al.
Molecules (Basel, Switzerland), 25(5) (2020-03-04)
A series of branched tetrapeptide Schiff bases 3-6 were designed and synthesized from corresponding tetrapeptide hydrazide 2 as a starting material.In vitroevaluation of the synthesized compounds 4-6 against breast MCF-7 carcinoma cells identified their excellent anticancer potency, with IC50 ranging
John A G Moir et al.
Pancreas, 49(10), 1364-1371 (2020-10-31)
Pancreatic stellate cells (PSCs) play a key metabolic role within the tumor microenvironment (stroma) of pancreatic ductal adenocarcinoma (PDAC), being glycolytic and associated with protumorigenic acidification from excess lactate. This study investigates the clinical significance of glycolytic enzyme lactate dehydrogenase
Guorong Cheng et al.
Talanta, 209, 120554-120554 (2020-01-02)
Lactate dehydrogenase (LDH), catalyzing the conversion of pyruvate to lactate during glycolysis, is overexpressed in cancer cells. LDH inhibitors are a promising approach for the treatment of cancer. But up till now, there is limited method for rapid screening of
Jilong Zhou et al.
Biology of reproduction, 99(2), 308-318 (2018-03-17)
Autophagy is an essential cellular mechanism that degrades cytoplasmic proteins and organelles to recycle their components. Here we showed that autophagy was essential for the glycolysis switch and energy homeostasis in mouse granulosa cells under hypoxic condition. Our data indicated
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