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Merck
CN
所有图片(1)

主要文件

SML0773

Sigma-Aldrich

GSK-650394

≥98% (HPLC)

别名:

2-环戊基-4-(5-苯基-1H-吡咯并[2,3-B]吡啶-3-基)苯甲酸, GSK 650394, GSK650394

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About This Item

经验公式(希尔记法):
C25H22N2O2
分子量:
382.45
UNSPSC代码:
12352200
NACRES:
NA.77

质量水平

方案

≥98% (HPLC)

表单

powder

颜色

white to beige

溶解性

DMSO: 20 mg/mL, clear

储存温度

room temp

SMILES字符串

[nH]1c2ncc(cc2c(c1)c4cc(c(cc4)C(=O)O)C5CCCC5)c3ccccc3

InChI

1S/C25H22N2O2/c28-25(29)20-11-10-18(12-21(20)17-8-4-5-9-17)23-15-27-24-22(23)13-19(14-26-24)16-6-2-1-3-7-16/h1-3,6-7,10-15,17H,4-5,8-9H2,(H,26,27)(H,28,29)

InChI key

WVSBGSNVCDAMCF-UHFFFAOYSA-N

应用

GSK-650394已被用作血清和糖皮质激素激活激酶(SGK1)抑制剂。

生化/生理作用

GSK-650394对血清和糖皮质激素激活激酶1(SGK1)的 IC50 值为62 nM ,对SGK2的IC50值为103 nM。 它能够在对细胞无毒的浓度下阻止病毒复制。
GSK-650394是一种有效的选择性SGK1拮抗剂。
GSK-650394是一种有效的选择性血清和糖皮质激素调节激酶1(SGK1)拮抗剂。

特点和优势

《受体分类和信号转导》手册的 PKB/Akt 页面有该化合物的介绍。想要浏览手册的其他页面, 请单击此处

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable


历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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访问文档库

W Bruce Sneddon et al.
The Journal of biological chemistry, 291(36), 18632-18642 (2016-07-20)
Parathyroid hormone (PTH) and FGF23 are the primary hormones regulating acute phosphate homeostasis. Human renal proximal tubule cells (RPTECs) were used to characterize the mechanism and signaling pathways of PTH and FGF23 on phosphate transport and the role of the
Judith G Alamares-Sapuay et al.
Journal of virology, 87(10), 6020-6026 (2013-03-15)
We previously performed a small interfering RNA (siRNA) screen and identified serum- and glucocorticoid-regulated kinase 1 (SGK1) as a host factor required for influenza A virus replication. However, the role of SGK1 in the influenza viral life cycle has never
Convergent Signaling Pathways Regulate Parathyroid Hormone and Fibroblast Growth Factor-23 Action on NPT2A-mediated Phosphate Transport.
Sneddon WB
The Journal of Biological Chemistry, 291(36), 18632-18642 (2016)
Ferran Medina-Jover et al.
FEBS letters, 594(19), 3200-3215 (2020-08-09)
BMP9 is a cytokine involved in the maturation phase of the angiogenic process that signals through its serine/threonine receptor ALK1 and its coreceptor endoglin. In this paper, we explain how BMP9 directs the regulation of endothelial cell proliferation blockage while

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