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Merck
CN

SML0764

Senktide trifluoroacetate salt

≥95% (HPLC)

别名:

DFFGLM (Modifications: Asp-1 = Succinyl-Asp, Phe-3 = Me-Phe, Met-6 = C-terminal amide) trifluoroacetate salt, Suc-Asp-Phe-MePhe-Gly-Leu-Met-NH2 trifluoroacetate salt

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关于此项目

经验公式（希尔记法）:
C40H55N7O11S · xC2HF3O2
化学文摘社编号:
106128-89-6
分子量:
841.97 (free base basis)
UNSPSC Code:
12352200
NACRES:
NA.77
Assay:
≥95% (HPLC)
Form:
film
Quality level:
100
Storage condition:
desiccated

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SMILES string

S(CC[C@H](NC(=O)[C@@H](NC(=O)CNC(=O)[C@@H](N(C)C(=O)[C@@H](NC(=O)[C@@H](NC(=O)CCC(=O)O)CC(=O)O)Cc2ccccc2)Cc1ccccc1)CC(C)C)C(=O)N)C

InChI

1S/C40H55N7O11S/c1-24(2)19-28(37(55)45-27(36(41)54)17-18-59-4)44-33(49)23-42-39(57)31(21-26-13-9-6-10-14-26)47(3)40(58)30(20-25-11-7-5-8-12-25)46-38(56)29(22-35(52)53)43-32(48)15-16-34(50)51/h5-14,24,27-31H,15-23H2,1-4H3,(H2,41,54)(H,42,57)(H,43,48)(H,44,49)(H,45,55)(H,46,56)(H,50,51)(H,52,53)/t27-,28-,29-,30-,31-/m0/s1

InChI key

HMHYXLVEFVGOPM-QKUYTOGTSA-N

assay

≥95% (HPLC)

form

film

storage condition

desiccated

color

colorless

shipped in

wet ice

storage temp.

−20°C

Quality Level

100

相关类别

Biochem/physiol Actions

Senktide is a selective Neurokinin NK3 tachykinin receptor agonist.
Senktide is a selective Neurokinin NK3 tachykinin receptor agonist. Neurokinins (tachykinins) are members of a family of at least three neuropeptides, substance P, neurokinin A, and neurokinin B (NKB), with each mediating their biological effects through binding to a preferred G-protein-coupled receptor termed NK1, NK2, or NK3, respectively. All three NK receptors are expressed in regions of the central nervous system that are related to emotion and cognition (i.e., amygdala and hippocampus) and have been linked to various degrees in psychiatric disorders. Neurokinin receptors, including NK3 receptors, are also expressed in the motor and sensory systems of the digestive tract.
Senktide treatment in follicular phase goats enhances the liberation of luteinizing hormone (LH) and advance the time of ovulation. Senktide has the ability to suppress gonadotropin-releasing hormone (GnRH) transcription. Treatment with senktide stimulates c-Fos and improve activator protein-1 (AP-1) activity.

存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

法规信息

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分析证书(COA)

Lot/Batch Number
0000360531
0000360531
0000156263
0000157523
0000156264

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Ovarian and hormonal responses to single or continuous peripheral administration of senktide, a neurokinin 3 receptor agonist, during the follicular phase in goats.
Endo N, et al.
Domestic Animal Endocrinology, 53, 136-143 (2015)
Neurokinin B Causes Acute GnRH Secretion and Repression of GnRH Transcription in GT1?7 GnRH Neurons.
Glidewell-Kenney CA, et al.
Molecular Endocrinology, 27(3), 437-454 (2013)
P Grachev et al.
Endocrinology, 155(7), 2589-2601 (2014-04-09)
Acute systemic stress disrupts reproductive function by inhibiting pulsatile gonadotropin secretion. The underlying mechanism involves stress-induced suppression of the GnRH pulse generator, the functional unit of which is considered to be the hypothalamic arcuate nucleus kisspeptin/neurokinin B/dynorphin A neurons. Agonists

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