所有图片(1)
别名:
(2S,3S)-3-(2-Methoxybenzylamino)-2-phenylpiperidine dihydrochloride, CP-99,994, CP-99994, CP99,994, CP99994
经验公式（希尔记法）:
C19H24N2O · 2HCl
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质量水平
检测方案
≥98% (HPLC)
形式
powder
储存条件
desiccated
颜色
white to beige
溶解性
H2O: 15 mg/mL, clear
储存温度
2-8°C
InChI
1S/C19H24N2O.2ClH/c1-22-18-12-6-5-10-16(18)14-21-17-11-7-13-20-19(17)15-8-3-2-4-9-15;;/h2-6,8-10,12,17,19-21H,7,11,13-14H2,1H3;2*1H/t17-,19-;;/m0../s1
InChI key
WNHRFWPLRATIDT-FFUVTKDNSA-N
生化/生理作用
(+)-CP-99994 dihydrochloride is an effective and selective non-peptide substance P receptor antagonist. It is synthesized from allylic and homoallylic C-H diamination of 4-phenyl-1-butene. (+)-CP-99994 exhibits anti-emetic activity in ferrets.
(+)-CP-99994 is a selective neurokinin (NK)-1 tachykinin antagonist. (+)-CP-99994 binds selectively and with high affinity with a Ki of 0.25 nM in a human cell line.
警示用语：
Warning
危险声明
预防措施声明
危险分类
Aquatic Acute 1 - Aquatic Chronic 1
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
Effects of HSP-117, a novel tachykinin NK1-receptor antagonist, on cisplatin-induced pica as a new evaluation of delayed emesis in rats.
Saeki M, et al.
Japanese Journal of Pharmacology, 86(3), 359-362 (2001)
Synthesis of (+)-CP-99,994 via Pd (0)-Catalyzed Asymmetric Allylic and Homoallylic C? H Diamination of Terminal Olefin.
Fu R, et al.
The Journal of Organic Chemistry, 74(19), 7577-7580 (2009)
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