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Merck
CN
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主要文件

SML0749

Sigma-Aldrich

SC79

≥97% (NMR)

别名:

2-氨基-6-氯-α-氰基-3-(乙氧基羰基)-4H-1-苯并吡喃-4-乙酸乙酯

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About This Item

经验公式(希尔记法):
C17H17ClN2O5
分子量:
364.78
UNSPSC代码:
12352200
NACRES:
NA.77

质量水平

方案

≥97% (NMR)

表单

powder

颜色

white to beige

溶解性

DMSO: 20 mg/mL, clear

储存温度

−20°C

SMILES字符串

Clc1cc2c(cc1)OC(=C(C2C(C(=O)OCC)C#N)C(=O)OCC)N

InChI

1S/C17H17ClN2O5/c1-3-23-16(21)11(8-19)13-10-7-9(18)5-6-12(10)25-15(20)14(13)17(22)24-4-2/h5-7,11,13H,3-4,20H2,1-2H3

InChI key

DXVKFBGVVRSOLI-UHFFFAOYSA-N

应用

SC79 可在蛋白质印迹分析中作为阳性对照,用于测定 Akt 的磷酸化程度以及激活已经被氯化尼替丁(一种天然生物活性生物碱)抑制的 Akt。

生化/生理作用

SC79 是一种 AKT 激活剂。SC79 与 Akt 的 plecktrin 同源性(PH)结构域结合,其模拟 PtdIns(3,4,5)P3 的结合以诱导 Akt 中的构象变化,其增强磷酸化和活化。SC79 在基于细胞的测定中诱导胞质 Akt 信号传导,并防止中风小鼠模型中的神经元死亡。

特点和优势

《受体分类和信号转导》手册的 PKB/Akt 页面有该化合物的介绍。想要浏览手册的其他页面, 请单击此处

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable


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分析证书(COA)

Lot/Batch Number

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访问文档库

Dokyun Na et al.
Molecular systems biology, 19(12), e11801-e11801 (2023-11-21)
The accumulation of misfolded and aggregated proteins is a hallmark of neurodegenerative proteinopathies. Although multiple genetic loci have been associated with specific neurodegenerative diseases (NDs), molecular mechanisms that may have a broader relevance for most or all proteinopathies remain poorly
Circadian Period 2 (Per2) downregulate inhibitor of differentiation 3 (Id3) expression via PTEN/AKT/Smad5 axis to inhibits glioma cell proliferation.
Zhang, et al.
Bioengineered, 13, 12350-12364 (2022)
Rongrong Huang et al.
Neoplasma (2021-10-15)
According to our previous research, phycocyanin (PC) could inhibit pancreatic tumor growth obviously. However, little is known about the effects of phycocyanin on pancreatic tumor metastasis. This study was aimed to investigate whether phycocyanin inhibits pancreatic cancer cells' metastasis and
Nitidine chloride inhibits the malignant behavior of human glioblastoma cells by targeting the PI3K/AKT/mTOR signaling pathway.
Liu M, et al.
Oncology Reports, 36(4), 2160-2168 (2016)
Silver nanoparticles suppresses brain-derived neurotrophic factor-induced cell survival in the human neuroblastoma cell line SH-SY5Y.
Park J H, et al.
Journal of Industrial and Engineering Chemistry, 47 , 62-73 (2017)

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