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Merck
CN

SML0749

Sigma-Aldrich

SC79

≥97% (NMR)

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别名:
2-氨基-6-氯-α-氰基-3-(乙氧基羰基)-4H-1-苯并吡喃-4-乙酸乙酯
经验公式(希尔记法):
C17H17ClN2O5
分子量:
364.78
UNSPSC代码:
12352200
NACRES:
NA.77

质量水平

检测方案

≥97% (NMR)

形式

powder

颜色

white to beige

溶解性

DMSO: 20 mg/mL, clear

储存温度

−20°C

InChI

1S/C17H17ClN2O5/c1-3-23-16(21)11(8-19)13-10-7-9(18)5-6-12(10)25-15(20)14(13)17(22)24-4-2/h5-7,11,13H,3-4,20H2,1-2H3

InChI key

DXVKFBGVVRSOLI-UHFFFAOYSA-N

应用

SC79 可在蛋白质印迹分析中作为阳性对照,用于测定 Akt 的磷酸化程度以及激活已经被氯化尼替丁(一种天然生物活性生物碱)抑制的 Akt。

生化/生理作用

SC79 是一种 AKT 激活剂。SC79 与 Akt 的 plecktrin 同源性(PH)结构域结合,其模拟 PtdIns(3,4,5)P3 的结合以诱导 Akt 中的构象变化,其增强磷酸化和活化。SC79 在基于细胞的测定中诱导胞质 Akt 信号传导,并防止中风小鼠模型中的神经元死亡。

特点和优势

《受体分类和信号转导》手册的 PKB/Akt 页面有该化合物的介绍。想要浏览手册的其他页面, 请单击此处

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable


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