所有图片(1)

主要文件

COO原产地证书/COA分析证书

安全信息

安全和法规

SML0745

NS6180

Name: NS6180
Brand: SIGMA

≥98% (HPLC)

别名:

4-[[3-(Trifluoromethyl)phenyl]methyl]-2H-1,4-benzothiazin-3(4H)-one

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About This Item

经验公式（希尔记法）:

C₁₆H₁₂F₃NOS

CAS号:

353262-04-1

分子量:

323.33

UNSPSC代码:

12352200

NACRES:

NA.77

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Sigma-Aldrich

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Sigma-Aldrich

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Sigma-Aldrich

SML2039

SAK3

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Y0002149

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Sigma-Aldrich

538944

U-46619

Sigma-Aldrich

E7034

EX-527

Sigma-Aldrich

S6510

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质量水平

100

方案

≥98% (HPLC)

表单

powder

颜色

white to beige

溶解性

DMSO: 20 mg/mL, clear

储存温度

2-8°C

SMILES字符串

FC(F)(F)c1cc(ccc1)CN2c3c(cccc3)SCC2=O

InChI

1S/C16H12F3NOS/c17-16(18,19)12-5-3-4-11(8-12)9-20-13-6-1-2-7-14(13)22-10-15(20)21/h1-8H,9-10H2

InChI key

ZUIJXKLTUFCDGO-UHFFFAOYSA-N

生化/生理作用

NS6180 is a novel inhibitor of the intermediate-conductance Ca2+-activated K+ channel (K_Ca3.1) The IC₅₀ of NS6180 against cloned human K_Ca3.1 is 9 nM. The compound blocks proliferation and production of IL-2 and IFNγ with sub-micromolar potencies in either ConA or PMA/ionomycin challenged rat splenocytes.

NS6180 is a novel inhibitor of the intermediate-conductance Ca2+-activated K+ channel (K_Ca3.1).