SML0739
TAPI-1 acetate salt
≥97% (HPLC)
别名:
N-[(2R)-2-[2-(Hydroxyamino)-2-oxoethyl]-4-methyl-1-oxopentyl]-3-(2-naphthalenyl)-L-alanyl-N-(2-aminoethyl)-L-Alaninamide acetate salt
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所有图片(1)
About This Item
经验公式（希尔记法）:
C26H37N5O5 · xC2H4O2
CAS号:
分子量:
499.60 (free base basis)
UNSPSC代码:
12352200
NACRES:
NA.77
推荐产品
质量水平
方案
≥97% (HPLC)
表单
powder
颜色
white to beige
运输
wet ice
储存温度
−20°C
SMILES字符串
N(O)C(=O)C[C@@H](CC(C)C)C(=O)N[C@@H](Cc1cc2c(cc1)cccc2)C(=O)N[C@@H](C)C(=O)NCCN
InChI
1S/C26H37N5O5/c1-16(2)12-21(15-23(32)31-36)25(34)30-22(26(35)29-17(3)24(33)28-11-10-27)14-18-8-9-19-6-4-5-7-20(19)13-18/h4-9,13,16-17,21-22,36H,10-12,14-15,27H2,1-3H3,(H,28,33)(H,29,35)(H,30,34)(H,31,32)/t17-,21+,22-/m0/s1
InChI key
AWNBSWDIOCXWJW-WTOYTKOKSA-N
应用
TAPI-1 acetate salt has been used as a tumor necrosis factor(TNF)-α convertase/ADAM17/α-secretase (TACE) inhibitor.
生化/生理作用
TAPI-1 is a potent inhibitor of matrix metalloproteinases and TACE (TNF-α convertase/ADAM17/α-secretase).
TAPI-1 is a potent inhibitor of matrix metalloproteinases and TACE.
警示用语：
Danger
危险声明
危险分类
Acute Tox. 3 Oral
储存分类代码
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
新产品
历史批次信息供参考:
分析证书(COA)
Lot/Batch Number
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Kahr W H A, et al.
Nature Communications, 8, 14816-14816 (2017)
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Shi Z, et al.
FEBS Journal, 284(7), 1096-1109 (2017)
Laura M Breshears et al.
The Journal of biological chemistry, 287(39), 32578-32587 (2012-07-27)
Staphylococcal superantigens (SAgs), such as toxic shock syndrome toxin-1 (TSST-1), are the main cause of toxic shock syndrome (TSS). SAgs deregulate the host immune system after penetrating epithelial barriers such as the vaginal mucosa. In response to TSST-1, human vaginal
Vincent Lin et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 31(43), 15329-15339 (2011-10-28)
The capacity of adult mammals to regenerate sensory hair cells is not well defined. To explore early steps in this process, we examined reactivation of a transiently expressed developmental gene, Atoh1, in adult mouse utricles after neomycin-induced hair cell death
The iRhom homology domain is indispensable for ADAM17-mediated TNFα and EGF receptor ligand release.
Stefan Düsterhöft et al.
Cellular and molecular life sciences : CMLS, 78(11), 5015-5040 (2021-05-06)
Membrane-tethered signalling proteins such as TNFα and many EGF receptor ligands undergo shedding by the metalloproteinase ADAM17 to get released. The pseudoproteases iRhom1 and iRhom2 are important for the transport, maturation and activity of ADAM17. Yet, the structural and functional
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