推荐产品
产品名称
MitoTEMPO, ≥98% (HPLC)
质量水平
方案
≥98% (HPLC)
表单
powder
储存条件
desiccated
protect from light
颜色
white to light brown
溶解性
H2O: 10 mg/mL, clear
储存温度
−20°C
SMILES字符串
[P+](CC(=O)NC4CC(N(C(C4)(C)C)[O])(C)C)(c3ccccc3)(c2ccccc2)c1ccccc1.[Cl-]
InChI
1S/C29H34N2O2P.ClH/c1-28(2)20-23(21-29(3,4)31(28)33)30-27(32)22-34(24-14-8-5-9-15-24,25-16-10-6-11-17-25)26-18-12-7-13-19-26;/h5-19,23H,20-22H2,1-4H3;1H
InChI key
WKKFJIJNGHNQQW-UHFFFAOYSA-N
应用
MitoTEMPO已被用作线粒体靶向抗氧化剂。
生化/生理作用
MitoTEMPO是一种线粒体靶向抗氧化剂，一种线粒体超氧化物的特异清除剂。
MitoTEMPO是一种线粒体靶向抗氧化剂，一种线粒体超氧化物的特异清除剂。 MitoTEMPO是抗氧化剂哌啶硝基氧TEMPO与亲脂阳离子三苯基鏻的组合，使MitoTEMPO能够轻松通过脂质双层膜，并在线粒体中积累数百倍。 线粒体功能障碍和氧化应激可导致多种疾病，包括心血管、肾脏、肝脏疾病、帕金森′s病和阿尔茨海默′s病。
其他说明
光敏性
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
历史批次信息供参考:
分析证书(COA)
Lot/Batch Number
Modulation of mitochondrial antiviral signaling by human herpesvirus 8 interferon regulatory factor 1
Young KH, et al.
Journal of Virology (2016)
Caveolin 1-related autophagy initiated by aldosterone-induced oxidation promotes liver sinusoidal endothelial cells defenestration
Xiaoying L, et al.
Redox Biology, 508-521 (2017)
Regulation of morphine-induced synaptic alterations: Role of oxidative stress, ER stress, and autophagy
Yu C, et al.
The Journal of Biological Chemistry (2016)
Eunice E To et al.
Antioxidants & redox signaling, 32(13), 929-942 (2019-06-14)
Aims: Reactive oxygen species (ROS) are highly reactive molecules generated in different subcellular sites or compartments, including endosomes via
Zimei Wu et al.
Zebrafish, 16(2), 171-181 (2019-02-07)
Chemical interventions are regularly used to examine and manipulate macrophage function in larval zebrafish. Given chemicals are typically administered by simple immersion or injection, it is not possible to resolve whether their impact on macrophage function is direct or indirect.
商品
DISCOVER Bioactive Small Molecules for Nitric Oxide & Cell Stress Research
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