所有图片(1)
别名:
(E)-克罗米芬 盐酸盐, 2- [4-\ [(1E)-2-氯-1,2-二苯乙烯基] 苯氧基]-N,N-二乙基-乙胺 盐酸盐, 2- [对-（2-氯-反式-1,2-二苯基乙烯基）苯氧基] 三乙胺 盐酸盐, ICI 46476, 反式氯米芬 盐酸盐
经验公式（希尔记法）:
C26H28ClNO · HCl
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质量水平
检测方案
≥96% (HPLC)
形式
powder
储存条件
protect from light
颜色
white to beige
溶解性
H2O: 10 mg/mL, clear
储存温度
2-8°C
InChI
1S/C26H28ClNO.ClH/c1-3-28(4-2)19-20-29-24-17-15-22(16-18-24)25(21-11-7-5-8-12-21)26(27)23-13-9-6-10-14-23;/h5-18H,3-4,19-20H2,1-2H3;1H/b26-25+;
InChI key
KKBZGZWPJGOGJF-BTKVJIOYSA-N
生化/生理作用
顺式克罗米酚是一种非甾体雌激素受体拮抗剂，可促进睾丸分泌促性腺激素依赖性睾酮。顺式克罗米酚是克罗米芬的反式异构体，约为反式（顺式克罗米酚）和顺式（逆式克罗米酚）的 60-40 混合物。顺式克罗米酚（反式克罗米酚）是一种雌激素拮抗剂，而逆式克罗米酚（顺式克罗米酚）是一种混合激动剂，具有雌激素活性，因此常见的副作用有时见于男性。顺式克罗米酚异构体负责抗雌激素活性和下丘脑-垂体-性腺轴的恢复。在最近的临床试验中，顺式克罗米酚使继发性性腺机能减退男性的血清 LH 和 FSH 升高，同时睾酮升高。顺式克罗米酚表现出总体上优于睾酮凝胶的效果，睾酮凝胶可升高血清睾酮，但同时可降低 LH 和 FSH。
其他说明
光敏感
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
新产品
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The Journal of clinical endocrinology and metabolism, 98(10), 4170-4175 (2013-08-28)
Elevated serum anti-Müllerian hormone (AMH) concentration in women with polycystic ovarian syndrome (PCOS) is known to lower sensitivity of ovarian follicles to circulating FSH. This effect may compromise the outcome of clomiphene citrate (CC) ovulation induction. The objective of the
Simon McDowell et al.
The Australian & New Zealand journal of obstetrics & gynaecology, 53(4), 395-398 (2013-07-09)
Clomiphene citrate is a widely used treatment for ovulatory dysfunction in women seeking pregnancy. The major adverse consequence of clomiphene use is the increased risk of multiple and higher-order multiple pregnancy. Mechanisms for multiple pregnancy include dosing variation, adjuvant therapies
M Sunj et al.
Human reproduction (Oxford, England), 28(9), 2417-2424 (2013-07-04)
Does unilateral volume-adjusted laparoscopic diathermy increase the chances of ovulation in women with polycystic ovary syndrome (PCOS)? Although unilateral laparoscopic ovarian drilling (ULOD) using adjusted thermal doses was more efficient than bilateral laparoscopic ovarian drilling (BLOD) using fixed doses, the
Renato Pasquali et al.
Frontiers of hormone research, 40, 83-102 (2013-09-05)
From the conceptual point of view, there are several reasons to expect that improvement of insulin sensitivity may produce several benefits in the treatment of a complex disorder like polycystic ovary syndrome (PCOS), including a decrease in insulin and androgen
Young Eun Jeon et al.
Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology, 29(9), 834-838 (2013-07-19)
Although a variety of factors have been reported as affecting pregnancy rates after intrauterine insemination (IUI), there have been conflicting results on prognostic factors. This study aimed to determine predictive factors for pregnancy in patients undergoing the first four IUI
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