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安全信息

SML0714

Sigma-Aldrich

FSLLRY-NH2 三氟乙酸盐

≥98% (HPLC)

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About This Item

经验公式(希尔记法):
C39H60N10O8 · xC2HF3O2
分子量:
796.96 (free base basis)
UNSPSC代码:
12352200
NACRES:
NA.77

质量水平

检测方案

≥98% (HPLC)

形式

powder

颜色

white to off-white

运输

wet ice

储存温度

−20°C

InChI

1S/C39H60N10O8/c1-22(2)17-30(36(55)45-28(11-8-16-44-39(42)43)35(54)46-29(33(41)52)20-25-12-14-26(51)15-13-25)47-37(56)31(18-23(3)4)48-38(57)32(21-50)49-34(53)27(40)19-24-9-6-5-7-10-24/h5-7,9-10,12-15,22-23,27-32,50-51H,8,11,16-21,40H2,1-4H3,(H2,41,52)(H,45,55)(H,46,54)(H,47,56)(H,48,57)(H,49,53)(H4,42,43,44)/t27-,28-,29-,30-,31-,32-/m0/s1

InChI key

KMSCNWHRNILNRJ-JNRWAQIZSA-N

Amino Acid Sequence

Phe-Ser-Leu-Leu-Arg-Tyr-NH2 trifluoroacetate salt

应用

FSLLRY-NH2 三氟醋酸盐可作为蛋白酶激活受体 2(PAR2)抑制剂,在小鼠模型中测试其对尿路感染的影响。此外,它也用于研究特应性皮炎(AD)相关急性瘙痒骤然加重小鼠模型中中至重度 AD 3 期临床试验的临床瘙痒数据集。

生化/生理作用

FSLLRY-NH2 是蛋白酶激活受体 2(PAR2)的肽拮抗剂。在啮齿类动物模型中,肽阻断激动剂诱导瘙痒。在基于细胞的试验中,肽抑制激动剂诱导的心肌细胞重塑和内皮细胞产生细胞因子。
FSLLRY-NH2降低内脏超敏反应(VH)的能力表明 PAR2 参与了 VH 的维持。

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

法规信息

常规特殊物品

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Ying-Jie Li et al.
Digestive diseases and sciences, 64(5), 1182-1192 (2018-12-19)
Mast cells (MCs), PAR2 and TRPV1, play a key role in the regulation of visceral pain. Several studies have found that probiotics regulate visceral sensitivity. The purpose of the current study was to explore the role of MC-PAR2-TRPV1 in VH
Fang Wang et al.
Cell, 184(2), 422-440 (2021-01-16)
Itch is an evolutionarily conserved sensation that facilitates expulsion of pathogens and noxious stimuli from the skin. However, in organ failure, cancer, and chronic inflammatory disorders such as atopic dermatitis (AD), itch becomes chronic, intractable, and debilitating. In addition to
Zonglong Wu et al.
American journal of physiology. Cell physiology, 317(3), C544-C555 (2019-06-27)
The specific regulatory mechanism of bladder urothelial barrier dysfunction after infection with uropathogenic Escherichia coli (UPEC) is still unclear. The cross talk between bladder urothelial cells and mast cells may play an important role during UPEC infection. In this study

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