质量水平
检测方案
≥98% (HPLC)
形式
powder
颜色
white to off-white
运输
wet ice
储存温度
−20°C
InChI
1S/C39H60N10O8/c1-22(2)17-30(36(55)45-28(11-8-16-44-39(42)43)35(54)46-29(33(41)52)20-25-12-14-26(51)15-13-25)47-37(56)31(18-23(3)4)48-38(57)32(21-50)49-34(53)27(40)19-24-9-6-5-7-10-24/h5-7,9-10,12-15,22-23,27-32,50-51H,8,11,16-21,40H2,1-4H3,(H2,41,52)(H,45,55)(H,46,54)(H,47,56)(H,48,57)(H,49,53)(H4,42,43,44)/t27-,28-,29-,30-,31-,32-/m0/s1
InChI key
KMSCNWHRNILNRJ-JNRWAQIZSA-N
Amino Acid Sequence
Phe-Ser-Leu-Leu-Arg-Tyr-NH2 trifluoroacetate salt
应用
FSLLRY-NH2 三氟醋酸盐可作为蛋白酶激活受体 2(PAR2)抑制剂,在小鼠模型中测试其对尿路感染的影响。此外,它也用于研究特应性皮炎(AD)相关急性瘙痒骤然加重小鼠模型中中至重度 AD 3 期临床试验的临床瘙痒数据集。
生化/生理作用
FSLLRY-NH2 是蛋白酶激活受体 2(PAR2)的肽拮抗剂。在啮齿类动物模型中,肽阻断激动剂诱导瘙痒。在基于细胞的试验中,肽抑制激动剂诱导的心肌细胞重塑和内皮细胞产生细胞因子。
FSLLRY-NH2降低内脏超敏反应(VH)的能力表明 PAR2 参与了 VH 的维持。
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
常规特殊物品
Digestive diseases and sciences, 64(5), 1182-1192 (2018-12-19)
Mast cells (MCs), PAR2 and TRPV1, play a key role in the regulation of visceral pain. Several studies have found that probiotics regulate visceral sensitivity. The purpose of the current study was to explore the role of MC-PAR2-TRPV1 in VH
Cell, 184(2), 422-440 (2021-01-16)
Itch is an evolutionarily conserved sensation that facilitates expulsion of pathogens and noxious stimuli from the skin. However, in organ failure, cancer, and chronic inflammatory disorders such as atopic dermatitis (AD), itch becomes chronic, intractable, and debilitating. In addition to
American journal of physiology. Cell physiology, 317(3), C544-C555 (2019-06-27)
The specific regulatory mechanism of bladder urothelial barrier dysfunction after infection with uropathogenic Escherichia coli (UPEC) is still unclear. The cross talk between bladder urothelial cells and mast cells may play an important role during UPEC infection. In this study
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