推荐产品
质量水平
方案
≥98% (HPLC)
表单
powder
储存条件
desiccated
颜色
white to light brown
溶解性
DMSO: 15 mg/mL, clear
储存温度
2-8°C
SMILES字符串
Cl.Ic1cnc(Nc2cccc(NC(=O)N3CCCC3)c2)nc1NCCCNC(=O)c4cccs4
InChI
1S/C23H26IN7O2S/c24-18-15-27-22(30-20(18)25-9-5-10-26-21(32)19-8-4-13-34-19)28-16-6-3-7-17(14-16)29-23(33)31-11-1-2-12-31/h3-4,6-8,13-15H,1-2,5,9-12H2,(H,26,32)(H,29,33)(H2,25,27,28,30)
InChI key
VAVXGGRQQJZYBL-UHFFFAOYSA-N
应用
BX-795盐酸盐已被用于研究激酶抑制对人内源性逆转录病毒（HERV）转录激活的影响。
生化/生理作用
BX-795会与3-磷酸肌醇依赖性激酶-1（PDK1）的底物ATP竞争它的ATP（三磷酸腺苷）结合口袋。体外检测表明BX-795可能会抑制Unc-51（丝氨酸/苏氨酸蛋白激酶）样自噬激活激酶（ULK1）。
BX-795最初被定性为3-磷酸肌醇依赖性激酶-1的一种有效抑制剂。利用BX-795进行的更多研究表明该分子也是IKKe和TBK1一种有效双重抑制剂，并已知其可通过干扰素调节因子3（IRF3）的磷酸化来调节干扰素的表达。
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
从最新的版本中选择一种：
分析证书(COA)
Lot/Batch Number
Nagarjuna R Cheemarla et al.
medRxiv : the preprint server for health sciences (2021-02-04)
The interferon response is a potent antiviral defense mechanism, but its effectiveness depends on its timing relative to viral replication. Here, we report viral replication and host response kinetics in patients at the start of SARS-CoV-2 infection and explore the
Richard I Feldman et al.
The Journal of biological chemistry, 280(20), 19867-19874 (2005-03-18)
The phosphoinositide 3-kinase/3-phosphoinositide-dependent kinase 1 (PDK1)/Akt signaling pathway plays a key role in cancer cell growth, survival, and tumor angiogenesis and represents a promising target for anticancer drugs. Here, we describe three potent PDK1 inhibitors, BX-795, BX-912, and BX-320 (IC(50)
Discovery and structure of a new inhibitor scaffold of the autophagy initiating kinase ULK1.
Lazarus M B and Kevan M S
Bioorganic & Medicinal Chemistry, 23(17), 5483-5488 (2015)
Compound signaling activates endogenous retroviruses by inducing enhancer and gene-neighborhood transcription.
Azebi S, et al.
bioRxiv, 284695-284695 (2018)
Weijian Ye et al.
PLoS pathogens, 14(10), e1007298-e1007298 (2018-10-05)
Natural killer (NK) cells provide the first line of defense against malaria parasite infection. However, the molecular mechanisms through which NK cells are activated by parasites are largely unknown, so is the molecular basis underlying the variation in NK cell
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