SML0693
LY-333531 盐酸盐
≥98% (HPLC)
别名:
(9S)-9-[(二甲氨基)甲基] -6,7,10,11-四氢-9H,18H-5,21:12,17-二甲基二苯并[e,k]吡咯并[3,4-h] [ 1,4,13]草二氮杂环十六烷-18,20(19H)-二酮 盐酸盐, 芦丁黄素
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关于此项目
Assay:
≥98% (HPLC)
Form:
powder
Quality level:
Storage condition:
desiccated, protect from light
Quality Level
assay
≥98% (HPLC)
form
powder
storage condition
desiccated, protect from light
color
orange-red
solubility
DMSO: 10 mg/mL, clear
storage temp.
−20°C
SMILES string
Cl.[n]21c3c(c(c2)C4=C(c5c6c([n](c5)CC[C@H](OCC1)CN(C)C)cccc6)C(=O)NC4=O)cccc3
InChI
1S/C28H28N4O3.ClH/c1-30(2)15-18-11-12-31-16-21(19-7-3-5-9-23(19)31)25-26(28(34)29-27(25)33)22-17-32(13-14-35-18)24-10-6-4-8-20(22)24;/h3-10,16-18H,11-15H2,1-2H3,(H,29,33,34);1H/t18-;/m0./s1
InChI key
NYQIEYDJYFVLPO-FERBBOLQSA-N
General description
LY-333531盐酸盐也被称为ruboxistaurin。
Application
LY-333531盐酸盐/ruboxistaurin已被用作PKCB阻断剂，以比较来源于受刺激的野生型细胞的磷酸肽与来源于PKCB敲除细胞或野生型细胞的磷酸肽。
Biochem/physiol Actions
LY333531是一种有效的PKCβ特异性抑制剂。
LY333531是蛋白激酶Cβ（PKCβ； PKCβ1和PKCβ2的IC50值分别为4.7和5.9 nM）的一种有效抑制剂。PKCβ亚型在氧化应激状态下过表达，尤其是与糖尿病有关。在糖尿病大鼠中，LY333531可改善视网膜的血流量和白细胞截留，并防止心肌肥大和心脏功能障碍。
Other Notes
光敏感
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Phosphorylation of residues inside the SNARE complex suppresses secretory vesicle fusion.
Malmersjo S, et al.
The Embo Journal, e201694071-e201694071 (2016)
Protein Kinase C β: a New Target Therapy to Prevent the Long-Term Atypical Antipsychotic-Induced Weight Gain.
Rimessi A, et al.
Neuropsychopharmacology, 42(7), 1491?1501-1491?1501 (2017)
Hongwei Yi et al.
Antioxidants & redox signaling, 30(17), 1949-1968 (2018-11-30)
Aims: Nonalcoholic fatty liver disease (NAFLD) is the most common cause of chronic liver diseases. However, there are no approved pharmacotherapies for the treatment of NAFLD other than managing life style and controlling diets. Extensive studies have demonstrated that multiple
全球贸易项目编号
| 货号 | GTIN |
|---|---|
| SML0693-1MG | 04061837101311 |