所有图片(1)
别名:
N-[(1S,2R)-3-[[(4-Aminophenyl)sulfonyl](2-methylpropyl)amino]-2-hydroxy-1-(phenylmethyl)propyl]carbamic acid (3S)-tetrahydro-3-furanyl ester, VX-478
经验公式（希尔记法）:
C25H35N3O6S
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质量水平
检测方案
≥98% (HPLC)
形式
powder
旋光性
[α]/D +8 to +12°, c = 0.5 in methanol
颜色
white to beige
溶解性
DMSO: 20 mg/mL, clear
储存温度
−20°C
InChI
1S/C25H35N3O6S/c1-18(2)15-28(35(31,32)22-10-8-20(26)9-11-22)16-24(29)23(14-19-6-4-3-5-7-19)27-25(30)34-21-12-13-33-17-21/h3-11,18,21,23-24,29H,12-17,26H2,1-2H3,(H,27,30)/t21-,23-,24+/m0/s1
InChI key
YMARZQAQMVYCKC-OEMFJLHTSA-N
一般描述
Amprenavir is a second-generation drug derived from hydroxyethylamine sulfonamide.
生化/生理作用
Amprenavir is an antiretroviral HIV Protease Inhibitor. It is the active metabolite of fosamprenavir.
Protease inhibition results in inactive and immature virus.
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
Molecular dynamics and free energy studies on the wild-type and double mutant HIV-1 protease complexed with amprenavir and two amprenavir-related inhibitors: mechanism for binding and drug resistance.
Hou T and Yu R
Journal of Medicinal Chemistry, 50(6), 1177-1188 (2007)
Satoko Matsunaga et al.
Journal of proteomics, 75(15), 4863-4873 (2012-06-13)
Xenotropic murine leukemia virus-related virus (XMRV) is a virus generated under artificial conditions by the recombination of 2 murine leukemia virus (MLV) proviruses, PreXMRV-1 and PreXMRV-2, during the in vivo passage of human prostate cancer cells in athymic nude mice.
Mary Beth Wire et al.
Clinical pharmacokinetics, 45(2), 137-168 (2006-02-21)
Fosamprenavir is one of the most recently approved HIV-1 protease inhibitors (PIs) and offers reductions in pill number and pill size, and omits the need for food and fluid requirements associated with the earlier-approved HIV-1 PIs. Three fosamprenavir dosage regimens
Mélanie Prague et al.
Computer methods and programs in biomedicine, 111(2), 447-458 (2013-06-15)
Models based on ordinary differential equations (ODE) are widespread tools for describing dynamical systems. In biomedical sciences, data from each subject can be sparse making difficult to precisely estimate individual parameters by standard non-linear regression but information can often be
Jenna A Rhoades et al.
Pharmaceutical research, 29(4), 972-982 (2011-12-14)
To predict and determine whether the protease inhibitors (PIs) nelfinavir, amprenavir, atazanavir, ritonavir, and saquinavir could serve as metabolic inhibitors of the human CES1 (hCES1) using both molecular modeling techniques and in vitro inhibition assays. Initially, a molecular modeling approach
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