SML0684
SF1670
≥98% (HPLC)
别名:
N-(9,10-Dihydro-9,10-dioxo-2-phenanthrenyl)-2,2-dimethyl-propanamide, N-(9,10-Dioxo-9,10-dihydro-phenanthren-2-yl)-2,2-dimethylpropionamide
SMILES string
N(c1cc2c(cc1)c3c(cccc3)C(=O)C2=O)C(=O)C(C)(C)C
InChI
1S/C19H17NO3/c1-19(2,3)18(23)20-11-8-9-13-12-6-4-5-7-14(12)16(21)17(22)15(13)10-11/h4-10H,1-3H3,(H,20,23)
InChI key
VZQDDSYKVYARDW-UHFFFAOYSA-N
assay
≥98% (HPLC)
form
powder
color
, light pink to red to very dark purple
solubility
DMSO: 10 mg/mL, clear
storage temp.
2-8°C
Quality Level
Application
SF1670 has been used:
- To study the effect of microRNA-30a on PTEN (phosphatase and tensin homologue deleted on chromosome 10 ) expression regulation.
- To study the formation of autophagosomes, induced by EGF (Epidermal growth factor) - dependent PTEN expression.
- To study the role of PTEN in the regulation of autophagy induction in human normal endometrial stromal cells.
Biochem/physiol Actions
PTEN prevents PI3-K(phosphoinositide 3-kinase)/Akt signaling pathway, which is very essential for neuronal regeneration. Therefore, inhibition of PTEN by SF1670 may support neuronal regeneration.
SF1670 is a selective PTEN (phosphatase and tensin homolog) inhibitor with an IC50 of 2 micromolar. PTEN inhibition by SF1670 was shown to increase neutrophil activity (polarization, phagocytosis, oxidative burst, and recruitment to site of infection), thereby enhancing the inflammatory response and bacteria-killing capacity of neutopenic mice.
SF1670 is a selective PTEN (phosphatase and tensin homolog) inhibitor.
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Bioinformatics prediction of miR-30a targets and its inhibition of cell proliferation of osteosarcoma by up-regulating the expression of PTEN.
Zhong B, et al.
BMC Medical Genomics, 10(1), 64-64 (2017)
Stefanie Kälin et al.
Cell metabolism, 26(3), 475-492 (2017-09-07)
Obesity and type 2 diabetes are associated with metabolic defects and adipose tissue inflammation. Foxp3
Aberrant PTEN expression in response to progesterone reduces endometriotic stromal cell apoptosis.
Choi J, et al.
Reproduction (Cambridge, England), 153(1), 11-21 (2017)
Thieu X Phan et al.
Scientific reports, 6, 39479-39479 (2016-12-21)
Sunlight has important biological effects in human skin. Ultraviolet (UV) light striking the epidermis catalyzes the synthesis of Vitamin D and triggers melanin production. Although a causative element in skin cancers, sunlight is also associated with positive health outcomes including
Paradoxical induction of growth arrest and apoptosis by EGF via the up-regulation of PTEN by activating Redox factor-1/Egr-1 in human lung cancer cells.
Ryu J W, et al.
Oncotarget, 8(3), 4181-4181 (2017)
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