所有图片(1)

主要文件

COO原产地证书/COA分析证书

SML0680

CYM-5541

Name: CYM-5541
Brand: SIGMA

≥98% (HPLC)

别名:

CYM5541, ML249, N,N-Dicyclohexyl(5-cyclopropylisoxazol-3-yl)-carboxamide, N,N-Dicyclohexyl-5-cyclopropyl-3-isoxazolecarboxamide

登录查看公司和协议定价

所有图片(1)

About This Item

经验公式（希尔记法）:

C₁₉H₂₈N₂O₂

CAS号:

945128-26-7

分子量:

316.44

UNSPSC代码:

12352211

NACRES:

NA.77

推荐产品

Slide 1 of 10

1 of 10

Sigma-Aldrich

C1997

CYM-5442

Sigma-Aldrich

J4080

JTE-013

USP

1270480

FTY720

Sigma-Aldrich

T1692

噻奈普汀钠盐水合物

Sigma-Aldrich

217714

5-氨基-3-（（4 -（氨基磺酰基）苯基）氨基）-N-（2，6-二氟苯基）-1H-1,2，4-三唑-1-硫代乙酰胺

Sigma-Aldrich

PZ0140

EBPC

Sigma-Aldrich

SML0700

FTY720

Sigma-Aldrich

SML2099

NIBR-0213

Sigma-Aldrich

SML2499

TY-52156

Sigma-Aldrich

5.31371

S1P Receptor 2 Agonist, CYM-5520

质量水平

100

方案

≥98% (HPLC)

表单

powder

颜色

white to beige

溶解性

DMSO: 5 mg/mL, clear (warmed)

储存温度

2-8°C

SMILES字符串

N(C4CCCCC4)(C3CCCCC3)C(=O)c1n[o]c(c1)C2CC2

InChI

1S/C19H28N2O2/c22-19(17-13-18(23-20-17)14-11-12-14)21(15-7-3-1-4-8-15)16-9-5-2-6-10-16/h13-16H,1-12H2

InChI key

NDKGACIWVAOUQH-UHFFFAOYSA-N

生化/生理作用

CYM-5541 is an allosteric agonist selective for the Sphingosine 1-phosphate (S1P) S1P3 receptor subtype.

CYM-5541 is an allosteric agonist selective for the Sphingosine 1-phosphate (S1P) S1P3 receptor subtype. CYM-5541 occupies a different chemical space in the ligand binding pocket of S1P3 than S1P does, a lower hydrophobic region around transmembrane helix TM6. CYM-5541 shows great selectivity and stability with an EC₅₀ of between 72 and 132 nM compared to S1P1 EC₅₀ > 10 μM, S1P2 EC₅₀> 50 μM, S1P4 EC₅₀ > 50 μM, and S1P5 EC₅₀ > 25 μM and no significant activities for a panel of 55 GPCRs, ion channels, and transporters.

特点和优势

This compound is featured on the Lysophospholipid Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.