SML0679
丹参素 钠盐
≥98% (HPLC)
别名:
(R)-α,3,4-三羟基-苯丙酸 钠盐, (R)-(+)-3-(3,4-二羟基苯基)乳酸, 3-(3′,4′-二羟基苯基)-(2R)-乳酸 钠盐, DS 182, 丹参素, 丹参酸 A
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关于此项目
经验公式（希尔记法）:
C9H9O5 · Na
化学文摘社编号:
分子量:
220.15
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
MDL number:
InChI
1S/C9H10O5.Na/c10-6-2-1-5(3-7(6)11)4-8(12)9(13)14;/h1-3,8,10-12H,4H2,(H,13,14);/q;+1/p-1/t8-;/m1./s1
SMILES string
OC1=C(O)C=CC(C[C@@H](O)C([O-])=O)=C1.[Na+]
InChI key
ZMMKVDBZTXUHFO-DDWIOCJRSA-M
assay
≥98% (HPLC)
form
powder
optical activity
[α]/D +30 to +40°, c = 1 in H2O
color
white to beige
solubility
H2O: 20 mg/mL, clear
storage temp.
2-8°C
Quality Level
Biochem/physiol Actions
丹参素具有心脏保护作用，可保护心肌免受输液损伤，并通过 Akt 和 ERK1/2 磷酸化抑制 H9c2 心肌细胞凋亡。
丹参素是丹参中的一种活性成分，可抑制活性氧形成，抑制血小板粘附和聚集，避免心肌缺血。丹参素具有心脏保护作用，可保护心肌免受输液损伤，并通过 Akt 和 ERK1/2 磷酸化抑制 H9c2 心肌细胞凋亡。
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Jian-ping Zhang et al.
Planta medica, 79(9), 744-752 (2013-05-24)
The traditional Chinese medicinal herb Danshen (Salvia miltiorrhiza), first recorded in the "Shen Nong's Herbal Classic", has long been used to treat cardiovascular conditions, although the mechanism(s) underlying its effects remain unclear. Here, an iron dextran injection (50 mg ·
Ye Jin et al.
Journal of pharmaceutical and biomedical analysis, 77, 32-39 (2013-01-30)
The application of near infrared (NIR) spectroscopy for on-line quantitative monitoring of alcohol precipitation of the Danhong injection was investigated. For the NIR measurements, two fiber optic probes designed to transmit NIR radiation through a 2mm path length flow cell
Libo Du et al.
Nanotoxicology, 7(3), 294-300 (2012-02-09)
To suppress the cytotoxicity of gold nanoparticles (AuNPs), danshensu, a naturally occurring polyphenol antioxidant isolated from Chinese herb, was used to provide a fundamental protection layer for AuNPs, to alleviate oxidative stress and as a reducing agent to react with
Yaoling Jia et al.
European journal of medicinal chemistry, 55, 176-187 (2012-07-31)
A series of novel amide and thioester conjugates between Danshensu and cysteine derivatives have been designed and synthesized based on the strategy of "medicinal chemical hybridization". Pharmacological evaluation indicated that the amide conjugates 3a/4a/17a and thioester conjugates 6a-d exhibited obvious
H Zhang et al.
The Journal of international medical research, 40(3), 943-953 (2012-08-22)
To investigate the effects of β-(3,4-dihydroxyphenyl)lactic acid on oxidative stress stimulated by high glucose levels in human peritoneal mesothelial cells (HPMCs) in vitro. HPMCs were incubated with 100 mol/l glucose followed by 0.625-20 mg/ml β-(3,4-dihydroxyphenyl)lactic acid. Reactive oxygen species (ROS)
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